槲皮素研究进展

Research progress on therapeutic potential of quercetin

槲皮素是一种天然存在的具有良好生物活性的植物化学物质,主要以糖苷的形式存在于蔬菜、水果、茶和葡萄酒等中,具有有益健康的作用。槲皮素是一种膳食多酚,通过饮食或作为食品补充剂可以从其保护作用中受益,与化学制剂相比,其来源广泛,安全易得。槲皮素的抗糖尿病,抗高血压病,抗阿尔茨海默病,抗关节炎,抗流感病毒,抗微生物感染,抗衰老,影响自噬及心血管保护作用已得到广泛研究,最近还报道了其对不同癌细胞系的抗癌活性研究。但由于槲皮素水溶性差,体内代谢快,半衰期短,导致其生物利用度低,从而限制了其在医药上的应用。槲皮素纳米粒和纳米载药系统是增强其生物利用度的有前景的平台,得到了显著利用。该文从临床前及临床2个方面综述了槲皮素的治疗潜力,提出了改进其生物利用度的解决方案,为天然化合物在医药领域的治疗应用提供指导和参考。

Quercetin is a naturally occurring phytochemical with good bioactivity,which mainly exists in the form of glycoside in vegetables,fruits,tea,and wine and exhibits beneficial health effects.Quercetin is a dietary polyphenol that exerts the protective effects through diet or use as a food supplement.Compared with chemical agents,quercetin is widely available and safe.Quercetin has been extensively studied for its anti-diabetic,anti-hypertensive,anti-Alzheimer′s disease,anti-arthritic,anti-influenza virus,anti-microbial infection,anti-aging,autophagy-regulating,and cardiovascular protective effects.Studies on its activities against different cancer cell lines have also been reported recently.However,the poor water solubility,rapid in vivo metabolism,and short half-life of quercetin have led to its low bioavailability,thus limiting its application in the field of medicine.Quercetin nanoparticles and nanoparticle drug delivery system have been effectively utilized for enhancing its bioavailability.This paper reviewed the therapeutic potential of quercetin from both preclinical and clinical aspects and proposed solutions to improve its bioavailability,so as to provide a reference for the therapeutic application of natural compounds in the field of medicine.