不同阿司匹林用药方案治疗川崎病对患儿丙种球蛋白用量及肝功能的影响观察

Effects of Different Aspirin Regimens on Gamma Globulin Dosage and Liver Function of Children Patients With Kawasaki Disease

目的观察不同阿司匹林用药方案对川崎病(KD)患儿丙种球蛋白用量及肝功能影响。方法选取入院治疗KD患儿86例,随机分为对照组和观察组各43例。两组均使用丙种球蛋白联合阿司匹林治疗。观察组患儿退热后逐步减少阿司匹林剂量,对照组患儿退热后直接减少阿司匹林剂量。比较治疗6周后两组疗效、各项临床症状缓解时间、平均丙种球蛋白用量及药物不良反应差异;比较治疗前及治疗6周后两组患儿肝功能指标[天门冬氨酸基转移酶(AST)、丙氨酸氨基转移酶(ALT)、谷氨酰转移酶(GGT)]差异。结果治疗6周后,观察组患儿治疗总有效率明显高于对照组(P<0.05);观察组患儿颈淋巴结肿胀、黏膜弥漫性充血等症状缓解时间均明显短于对照组,丙种球蛋白再注射率明显低于对照组(P<0.05);两组患儿AST、ALT、GGT指标水平较治疗前明显降低,且观察组显著低于同一时期对照组(P<0.05);两组患儿药物不良反应对比无统计学差异(P>0.05)。结论采用阿司匹林联合丙种球蛋白治疗川崎病能够加快患儿临床症状消失、提高疗效,具有较高临床推广价值。

Objective To observe the effects of different aspirin regimens on gamma globulin dosage and liver function of children patients with Kawasaki disease(KD).Methods 86 children patients with KD who were admitted to our hospital for treatment were selected and randomly divided into control group and observation group,with 43 cases in each group.Both groups were treated with gamma globulin combined with aspirin,and the children patients in observation group gradually reduced the aspirin dose after fever subsided,and the children patients in control group directly reduced the aspirin dose after fever subsided.The efficacy after 6 weeks of treatment,relief times of various clinical symptoms,average dose of gamma globulin and adverse drug reactions were compared between the two groups.The liver function indexes[aspartate minotransferase(AST),alanine aminotransferase(ALT),glutamyltransferase(GGT)]were compared between the two groups before treatment and after 6 weeks of treatment.Results After 6 weeks of treatment,the total effective rate of treatment in observation group was significantly higher than that in control group(P<0.05).The relief times of symptoms such as cervical lymph node swelling and diffuse mucosal hyperemia in observation group were significantly shorter than those in control group,and the re-injection rate of gammaglobulin was significantly lower than that in control group(P<0.05).The levels ofAST,ALTand GGT in the two groups were significantly lower than those before treatment,and the levels in observation group were significantly lower than those in control group during the same period(P<0.05).There were no significant differences in the adverse drug reactions between the two groups(P>0.05).Conclusion Aspirin combined with gamma globulin in the treatment of Kawasaki disease can speed up the disappearance of clinical symptoms and improve the efficacy,with high clinical promotion value.