血清Lp(a)、APN水平与糖尿病肾病患者肾损伤的相关性

Correlation Between Serum Lp(a),APN Levels and Renal Injury in Patients With Diabetic Nephropathy

目的探讨血清脂蛋白Lp(a)、脂联素(APN)水平与糖尿病肾病(DN)患者肾损伤的相关性。方法回顾性分析60例DN患者的临床资料纳入A组,并收集同期医院收治的60例单纯2型糖尿病患者(T2DM)患者的临床资料纳入B组。统计患者一般资料及实验室指标[Lp(a)、APN],重点分析Lp(a)、APN水平与DN患者肾损伤的相关性。结果A组中DN患者肾损伤分期:Ⅰ期0例、Ⅱ期0例、Ⅲ期52例、Ⅳ期8例、Ⅴ期0例。Ⅳ期患者的血清Lp(a)水平较Ⅲ期及B组患者高,且Ⅲ期较B组高,APN水平较Ⅲ期及B组患者低,且Ⅲ期较B组低,差异有统计学意义(P<0.05);双变量Pearson直线相关性分析结果显示,血清Lp(a)与DN患者肾损伤指标(UAER)呈正相关(r>0,P<0.001);APN与UAER呈负相关(r<0,P<0.001)。结论血清Lp(a)、APN水平与DN患者肾损伤存在一定联系,临床可通过监测患者血清Lp(a)、APN水平来评估DN患者肾损伤的发生及发展情况。

Objective To investigate the correlation between serum lipoprotein(a),LP(a),adiponectin(APN)levels and renal injury in patients with diabetic nephropathy(DN).Methods The clinical data of 60 patients with DN admitted were collected and included in group A,and the clinical data of 60 patients with simple type 2 diabetes mellitus(T2DM)admitted to the hospital during the same period were collected and included in group B.The general data of patients and laboratory indexes[Lp(a),APN]were collected,and the correlation between Lp(a),APN levels and renal injury in patients with DN was analyzed.Results In group A,there were 0 cases in stage Ⅰ,0 cases in stage Ⅱ,52 cases in stage Ⅲ,8 cases in stage Ⅳ and 0 cases in stage v.The level of serum Lp(a)in patients with stage Ⅳ was higher than that in patients with stage Ⅲ and group B,and the level of serum APN in patients with stage Ⅲ was lower than that in patients with stage Ⅲ and group B,and the difference was statistically significant(P<0.05);Pearson linear correlation analysis showed that serum Lp(a)was positively correlated with renal injury index(UAER)in patients with DN(r>0,P<0.001);APN was negatively correlated with UAER(r<0,P<0.001).Conclusion Serum Lp(a)and APN levels are associated with renal injury in patients with DN.The occurrence and development of renal injury in patients with DN can be evaluated by monitoring serum Lp(a)and APN levels.