盐酸法舒地尔联合阿司匹林治疗急性心肌梗死疗效对氧化应激、炎性指标的影响

Efficacy of Fasudil Hydrochloride Combined With Aspirin in the Treatment of Acute Myocardial Infarction and Its Influence on Oxidative Stress and Inflammatory Indexes

目的分析盐酸法舒地尔联合阿司匹林治疗急性心肌梗死的临床疗效及对氧化应激、炎性指标的影响。方法将我院收治的120例急性心肌梗死患者分为2组,即观察组和对照组各60例,对照组接受阿司匹林治疗,观察组在此基础上进行盐酸法舒地尔治疗,比较疗效及氧化应激指标、炎性指标。结果观察组疗效优于对照组;观察组治疗后SOD、NO高于对照组,MDA、AGEs低于对照组,差异存在统计学意义(P<0.05);白介素、肿瘤坏死因子等炎性指标均低于对照组(P<0.05)。结论盐酸法舒地尔与阿司匹林联合应用下可提高急性心肌梗死的治疗效果,降低炎性反应及氧化应激程度。

Objective To analyze the clinical efficacy of fasudil hydrochloride combined with aspirin in the treatment of acute myocardial infarction and its influence on oxidative stress and inflammatory indexes.Methods Totally 120 patients with acute myocardial infarction admitted to our hospital were divided into two groups,namely 60 cases in the observation group and 60 cases in the control group.The efficacy,oxidative stress indicators and inflammatory indexes were compared.Results The efficacy of the observation group was better than that of the control group.After treatment,the levels of SOD and NO of theobservation group were higher than those of the control group while the levels of MDA and AGEs were lower than those of the control group(P<0.05).The inflammatory indexes such as interleukins and tumor necrosis factor were lower than those of the control group(P<0.05).Conclusion The combined application of fasudil hydrochloride and aspirin can improve the therapeutic effect of acute myocardial infarction,and reduce the inflammatory reactions and oxidative stress degree.