4种不同浓度高渗盐水雾化治疗改善婴幼儿毛细支气管炎临床症状效果比较

Comparison of Effects of Four Different Concentrations of Hypertonic Saline Aerosol Treatment on Improving the Clinical Symptoms of Infant Bronchiolitis

目的比较4种不同浓度高渗盐水雾化治疗改善婴幼儿毛细支气管炎临床症状效果。方法将我院收治的200例毛细支气管炎婴幼儿作为研究对象,按照随机数字表法分为4组(A组、B组、C组、D组),均为50例。A组、B组、C组、D组分别采用3%、5%、6%、7%高渗盐水雾化治疗,对比其临床症状体征消失时间、Wang严重程度评分(CS)及不良反应。结果4组疗效比较差异不显著(P>0.05);4组治疗后CS评分比较差异不显著(P>0.05);4组临床症状体征消失时间比较差异不显著(P>0.05);A、B、C、D组不良反应发生率分别为0.00%、6.00%、12.00%、14.00%,C组和D组不良反应发生率高于A组(P<0.05)。结论4种不同浓度(3%、5%、6%、7%)高渗盐水雾化治疗均可以有效改善婴幼儿毛细支气管炎临床症状,但3%高渗盐水雾化治疗安全性更佳。

Objective To compare the effects of four different concentrations of hypertonic saline aerosol treatment on improving the clinical symptoms of infant bronchiolitis.Methods 200 infants with bronchiolitis admitted to our hospital were selected as the study subjects and divided into four groups(group A,group B,group C,and group D)according to the random number table method,with 50 cases in each group.Group A,group B,group C and group D were treated with 3%,5%,6%and 7%hypertonic salineaerosol treatment respectively.The disappearance timesof clinical symptoms and signs,Wang severity score(CS)and adverse reactions were compared.Results There was no significant difference in the efficacy among the four groups(P>0.05).There was no significant difference in the CS score among the four groups after treatment(P>0.05).There were no significant differences in the disappearance times of clinical symptoms and signs among the four groups(P>0.05).The incidence rates of adverse reactions in groups A,B,C,and D were 0.00%,6.00%,12.00%,and 14.00%respectively.The incidence rate of adverse reactions in groups C and D was higher than that in group A(P<0.05).ConclusionFour different concentrations(3%,5%,6%,7%)of hypertonic saline aerosol treatment can effectively improve the clinical symptoms of infantbronchiolitis,but 3%hypertonic saline aerosol treatment has better safety.