益生菌治疗心境障碍机制的研究进展

Research progress of probiotics mechanism in the treatment of mood disorders

近年来,心境障碍患者的肠道菌群紊乱逐渐受到人们的关注.肠道菌群经微生物-肠-脑(MGB)轴沟通中枢神经系统实现双向调节,影响人的认知、情绪和行为.益生菌及其产物重塑肠道微生态,改善免疫和内分泌系统功能,恢复神经递质水平.因此,应用益生菌调节失衡的肠道菌群,恢复紊乱的MGB轴正成为心境障碍的辅助疗法.但目前益生菌疗法仍存在一些问题,如菌株之间的差异性、肠道菌群组成的异质性等.未来需要进行更多试验以明确不同菌株作用机制,从而对不同亚型心境障碍患者针对性地使用益生菌,完善治疗策略.

In recent years,the presence of gut microflora dysbiosis among mood disorder patients has attracted more and more attention.The gut microhiota communicates with the central nervous system via the microbiota-gut-hrain(MGB)axis to achieve two-way regulation,which affects people's cognition,emotion and behavior.Probiotics and their products can reshape the intestinal microecology,improve the function of immune and endocrine systems,and restore the level of neurotransmitters.Therefore,the application of probiotics to regulate the imbalance of gut microhiota and restore the disorder of MGB axis is becoming an adjuvant therapy for mood disorders.However,there are still some problems in probiotic therapy,such as the heterogeneous nature of both the gut microhiota composition and probiotics strains.In the future,more trials are urgently needed to determine specific probiotics strains for different subtypes of mood disorders to improve the treatment strategy.