慢性间歇性缺氧致认知功能障碍与小胶质细胞相关性的研究进展

Research progress on the relationship between chronic intermittent hypoxia-induced cognitive dysfunction and microglia

阻塞性睡眠呼吸暂停综合征(OSAS)是一种常见的睡眠呼吸疾患,而慢性间歇性缺氧(CIH)是OSAS最重要的病理生理特征.近几年关于CIH致认知障碍的研究已成为热点,研究发现CIH可激活小胶质细胞引起神经炎症,释放炎性因子从而引起中枢神经系统损伤,进一步导致认知功能障碍.现就CIH激活小胶质细胞的方式,以及小胶质细胞参与CIH致认知功能障碍的分子机制作一综述,以期为下一步研究提供支持.

Obstructive sleep apnea syndrome(OSAS)is a common sleep breathing disorder,and chronic intermittent hypoxia(CIH)is the most important pathophysiological feature of it.In recent years,the research on CIH-induced cognitive impairment has become a hot spot.Research has found that CIH can activate microglia to cause neuroinflammation,release inflammatory factors,cause central nervous system damage,and further lead to cognitive dysfunction.This article reviews the ways in which CIH activates microglia,and the molecular mechanism of microglia's involvement in CIH-induced cognitive dysfunction,in order to provide support for further research.