中医药防治化疗后胃肠道反应的概况

Overview of Traditional Chinese Medicine in prevention and treatment of gastrointestinal reactions after chemotherapy

化疗是恶性肿瘤最重要、最常见的治疗手段之一,但化疗在杀伤肿瘤细胞同时,对机体也造成了一定程度的损害,主要包括胃肠道反应、血液系统毒性、周围神经毒性、心脏毒性等不良反应,其中恶心呕吐等胃肠道反应最为常见,严重影响患者生活质量,甚者影响正常治疗[1]。目前,西医治疗化疗后胃肠道反应的药物主要包括5-HT受体拮抗剂、NK-1受体拮抗剂、抗组胺药等,但长期应用可产生便秘、腹痛、头痛、心脏毒性等不良反应[2],急需探寻更佳的治疗手段。

Chemotherapy is one of the important treatment methods for malignant tumors. It is often accompanied by multiple organ function damage, among which gastrointestinal reactions are the most common. At present, there are various kinds of drugs to reduce gastrointestinal reactions in clinic. Long-term application has side effects such as constipation, abdominal distension and abdominal pain, and serious side effects may endanger life. Therefore, how to effectively reduce gastrointestinal reaction after chemotherapy is an urgent problem to be solved at this stage. To explore the superiority of TCM, this paper introduces from six aspects, which includes treatment individuality, treatment in different time, treatment with different measures characteristic external treatments, psychosomatic therapy and dietary modulation. It may provide reference for the treatment of gastrointestinal reactions after chemotherapy in the future.