摘要
With the rapid development of high-throughput sequencing and artificial intelligence(AI)techniques,gut mucosal microbiota begins to be recognized as critical drivers of human colorectal cancer(CRC).Various AI approaches have been designed to obtain effective information from enormous numbers of microbial cells residing in gut mucosal as well as cancer cells.These mainly include detection of microbial markers for early clinical diagnosis of stage-specific CRC,characterization of pathogenic bacterial activities via genomic and transcriptomic analyses,and prediction of interplay between bacterial drivers and host immune systems.Here I review the current progresses of AI applications in profiling gut microbiomes linked to CRC initiation and development.I further look forward to future AI research for improving our understanding of the roles of gut microbiota in CRC evolution.
