不同雾化吸入方法对慢性阻塞性肺疾病患者的影响研究

Effect of different aerosol inhalation methods on patients with chronic obstructive pulmonary disease

目的探讨在慢性阻塞性肺疾病(COPD)的治疗过程中采用不同的雾化吸入方法对患者的疗效及影响。方法90例COPD患者,依照雾化吸入方式的不同分为超声组(43例)与氧气组(47例)。超声组采取超声途径雾化吸入治疗,氧气组采取以氧气为媒介的雾化吸入治疗。比较两组雾化吸入前后的动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO2)、用力肺活量(FVC)、呼气峰值流速(PEF)、第1秒用力呼气容积(FEV1)/FVC水平。结果雾化吸入后,氧气组PaCO_(2)(45.58±3.52)mm Hg(1 mm Hg=0.133 kPa)低于超声组的(50.01±4.57)mm Hg,PaO2(79.07±7.91)mm Hg高于超声组的(70.21±5.97)mm Hg,差异有统计学意义(P<0.05)。雾化吸入后,氧气组FVC、PEF、FEV1/FVC水平分别为(3.47±0.68)L、(397.43±45.13)L/min、(64.88±7.05)%,均高于超声组的(2.93±0.62)L、(332.86±46.13)L/min、(60.03±6.24)%,差异有统计学意义(P<0.05)。结论COPD患者应用以氧气为媒介的雾化吸入方式治疗效果更优,建议临床首选。

Objective To discuss the efficacy of different aerosol inhalation methods on patients with chronic obstructive pulmonary disease(COPD).Methods A total of 90 patients with COPD were divided into ultrasound group(43 cases)and oxygen group(47 cases)according to different aerosol inhalation methods.The ultrasound group was treated with ultrasonic aerosol inhalation,and the oxygen group was treated with oxygen-based aerosol inhalation.Both groups were compared in terms of arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2)),forced vital capacity(FVC),peak expiratory flow(PEF),and forced expiratory volume in the 1st second(FEV1)/FVC before and after aerosol inhalation.Results After aerosol inhalation,PaCO_(2)(45.58±3.52)mm Hg(1 mm Hg=0.133 kPa)in the oxygen group was lower than(50.01±4.57)mm Hg in the ultrasound group,and PaO_(2)(79.07±7.91)mm Hg was higher than(70.21±5.97)mm Hg in the ultrasound group.All the differences were statistically significant(P<0.05).After aerosol inhalation,FVC,PEF,and FEV1/FVC levels in the oxygen group were(3.47±0.68)L,(397.43±45.13)L/min,and(64.88±7.05)%,respectively,which were higher than(2.93±0.62)L,(332.86±46.13)L/min,and(60.03±6.24)%in the ultrasound group,and the differences were statistically significant(P<0.05).Conclusion Oxygen-based aerosol inhalation has better therapeutic effect on patients with COPD,and it is recommended as the first choice in clinic.