胞二磷胆碱联合氯吡格雷治疗粥样硬化性脑梗死的疗效观察

Efficacy observation of citicoline combined with clopidogrel in the treatment of atherosclerotic cerebral infarction

目的评价胞二磷胆碱联合氯吡格雷治疗粥样硬化性脑梗死的效果。方法92例粥样硬化性脑梗死患者,按照1∶1比例法分为对照组与联合组,各46例。两组均进行控血压、降血糖等常规治疗,在此基础上,对照组患者采取氯吡格雷治疗,联合组患者采取胞二磷胆碱+氯吡格雷治疗。比较两组患者的临床疗效、不良反应发生情况以及治疗后的神经功能缺损情况与日常生活能力。结果联合组治疗总有效率93.48%高于对照组的76.09%,不良反应发生率8.70%低于对照组的23.91%,差异具有统计学意义(P<0.05)。联合组美国国立卫生研究院卒中量表(NIHSS)评分(11.50±2.20)分低于对照组的(16.60±2.50)分,Barthel指数(77.50±4.50)分高于对照组的(67.80±3.50)分,差异具有统计学意义(P<0.05)。结论胞二磷胆碱与氯吡格雷联合治疗满足粥样硬化性脑梗死患者的治疗需求,能够促进患者神经功能、日常生活能力提升,整体治疗效果显著、安全性高。

Objective To evaluate the effect of citicoline combined with clopidogrel in the treatment of atherosclerotic cerebral infarction.Methods A total of 92 patients with atherosclerotic cerebral infarction were divided into the control group and the combination group according to the 1∶1 ratio method,with 46 cases in each group.Both groups were treated with conventional treatments such as blood pressure control and blood glucose reduction.On this basis,patients in the control group were treated with clopidogrel,and patients in the combination group were treated with citicoline and clopidogrel.Both groups were compared in terms of clinical efficacy,occurrence of adverse reactions,and the neurological deficits and abilities of daily living after treatment.Results The total effective rate of treatment 93.48%in the combination group was higher than 76.09%in the control group,and the incidence of adverse reactions 8.70%was lower than 23.91%in the control group;all the differences were statistically significant(P<0.05).The National Institutes of Health stroke scale(NIHSS)score(11.50±2.20)points in the combination group was lower than(16.60±2.50)points in the control group,and the Barthel index score(77.50±4.50)points was higher than(67.80±3.50)points in the control group;all the differences were statistically significant(P<0.05).Conclusion The combined treatment of citicoline and clopidogrel meets the treatment needs of patients with atherosclerotic cerebral infarction,and it can promote the improvement of patients’neurological function and abilities of daily living,with significant overall therapeutic effects and high safety.