基于数据挖掘的中医药治疗急性白血病化疗后骨髓抑制期的临床用药规律研究

Clinical Medication Rule of Traditional Chinese Medicine in the Treatment of Bone Marrow Suppression Stage After Chemotherapy in Acute Leukemia Based on Data Mining

目的:挖掘中医药治疗急性白血病化疗后骨髓抑制期的用药规律。方法:检索中国知网、万方医学网和维普数据库中建库至2020年12月关于中医药治疗急性白血病化疗后骨髓抑制期的相关文献,采用Excel 2019、SPSS Modeler 18.0及SPSS Statistics 24.0软件,对方剂中的中药使用频次数、性味归经进行统计分析,并进行关联规则分析、聚类分析和因子分析。结果:共筛选出方剂131首,中药239味,药味以苦味、甘味为主,药性多为寒性、温性,药物归经以归肝经为主,其次为归脾经、肾经;以补虚药、清热解毒药及活血止血药居多。共得出关联规则19个,聚类分析可聚为6类,因子分析共提取8个公因子。结论:急性白血病化疗后骨髓抑制期以益气健脾、滋阴补血为主要治法,注重扶持正气。

OBJECTIVE:To probe into the medication rule of traditional Chinese medicine in the treatment of bone marrow suppression stage after chemotherapy in acute leukemia.METHODS:CNKI,Wanfang database and VIP database were retrieved to collect the literature of traditional Chinese medicine in the treatment of bone marrow suppression stage after chemotherapy in acute leukemia from the establishment of the database to Dec.2020.With the help of Excel 2019,SPSS Modeler 18.0 and SPSS Statistics 24.0 software,frequency analysis,flavor and meridian tropism,cluster analysis and factor analysis were statistically performed,and association rule analysis,cluster analysis and factor analysis were carried out.RESULTS:A total of 131 prescriptions were screened out,including 239 kinds of traditional Chinese medicine,the main drug taste were Ku and Gan,and the main characteristics were Han and Wen.The main channel tropisms were liver followed by spleen and kidney.Tonic drugs,heat-clearing and detoxifying drugs and blood-activating hemostatic drugs were mostly used.A total of 19 association rules were obtained,cluster analysis can be grouped into 6 categories,and 8 common factors were extracted by factor analysis.CONCLUSIONS:During the bone marrow suppression stage after chemotherapy in acute leukemia,the main treatment is spleen invigorating and kidney nourishing therapy,and to focus on fostering healthy Qi.