奥曲肽联合奥美拉唑治疗肝硬化合并上消化道出血疗效研究

Efficacy of Octreotide Combined With Omeprazole in the Treatment of Liver Cirrhosis Complicated With Upper Gastrointestinal Bleeding

目的分析奥曲肽联合奥美拉唑在肝硬化合并上消化道出血治疗中的应用效果。方法本研究76例肝硬化合并上消化道出血患者均为本院2019年1月—12月接收,依据平行对照法分组,入院后所有患者均进行对症支持治疗,在此基础上,实施垂体后叶素结合奥美拉唑治疗者为对照组(38例),采取奥曲肽结合奥美拉唑治疗者为观察组(38例),对治疗效果、不良反应发生率、住院时间、止血时间、NO浓度及血清胰高血糖素浓度进行对比分析。结果治疗总有效率和不良反应发生率方面,观察组(92.11%,7.89%)均比对照组(73.68%,28.95%)优,差异有统计学意义(P<0.05);和对照着相比,观察组止血时间、住院时间较短,组间对比差异有统计学意义(P<0.05)。治疗前,观察组与对照组NO浓度及血清胰高血糖素浓度对比,差异无统计学意义(P>0.05);治疗后两组指标进行比较,观察组两项指标均值低于对照组,差异有统计学意义(P<0.05)。结论肝硬化合并上消化道出血临床治疗期间,奥曲肽与奥美拉唑的联合应用,不仅可以减轻呕血、黑便等临床症状,提高治疗效果,而且可以减少患者住院时间,安全性高,除此之外,其能够有效改善患者血清胰岛血糖素浓度及NO浓度,以便患者及早恢复健康。

Objective To analyze the effect of octreotide combined with omeprazole in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding.Methods In this study,76 patients with liver cirrhosis and upper gastrointestinal bleeding were admitted in our hospital from January to December 2019.They were grouped according to the parallel control method.After admission,all patients received symptomatic and supportive treatment.On this basis,implementation Pituitrin combined with omeprazole were treated as the control group(38 cases),and octreotide combined with omeprazole was used as the observation group(38 cases).The effect of treatment,incidence of adverse reactions,length of hospital stay,and time of hemostasis,NO concentration and serum glucagon concentration were compared and analyzed.Results In terms of the total effective rate of treatment and the incidence of adverse reactions,the observation group(92.11%,7.89%)was better than the control group(73.68%,28.95%),and the difference was statistically significant(P<0.05);compared with the control group,The observation group had shorter hemostasis time and shorter hospital stay,and the difference in contrast between the groups was significant(P<0.05).Before treatment,the observation group was compared with the control group in NO concentration and serum glucagon concentration,and there was no significant difference(P>0.05);after treatment,the two indexes were compared,and the average value of the two indexes in the observation group was lower than that in the control group.Statistically significant(P<0.05).Conclusion During the clinical treatment of liver cirrhosis combined with upper gastrointestinal bleeding,the combined application of octreotide and omeprazole can not only reduce the clinical symptoms such as hematemesis and melena,improve the treatment effect,but also reduce the patient’s hospital stay,with high safety.In addition,it can effectively improve the patient's serum insulin concentration and NO concentration,so that patients can recover early.