^(68)Ga-PSMA-11 PET/CT延迟显像探测前列腺癌根治术后盆腔复发的价值

The value of^(68)Ga-PSMA-11 PET/CT delayed imaging in the detection of pelvic recurrence after radical prostatectomy

目的分析^(68)Ga-前列腺特异性膜抗(PSMA)-11 PET/CT延迟显像探测前列腺癌根治术后盆腔复发的价值。方法回顾性纳入本院行前列腺癌根治术的患者24例。患者注射显像剂后60 min行^(68)Ga-PSMA-11 PET/CT全身标准显像及180 min行局部盆腔延迟显像。比较标准显像及延迟显像探测盆腔复发病灶数目、大小、最大标准摄取值(SUVmax)及靶/本比(T/B)。结果24例患者中,盆腔复发患者17例。复发患者中标准显像阳性15例,延迟显像阳性17例。无复发患者7例,标准显像及延迟显像均呈阴性。标准显像探测盆腔复发灵敏度为82.24%(15/17),延迟显像灵敏度为100.0%(17/17),两者差异无统计学意义(χ^(2)=2.125,P=0.145)。延迟显像比标准显像多探测10个盆腔阳性病灶。延迟显像额外发现的盆腔病灶直径4(3,8)mm比标准显像发现的盆腔病灶直径8(7,12)mm更小(U=94,P=0.004)。延迟显像病灶SUVmax10.08(6.58,15.50)与标准显像7.89(4.87,15.26)相当(U=1204,P=0.234),但延迟显像病灶T/B值55.90(30.45,109.27)明显高于标准显像32.89(21.67,55.07)(U=840,P=0.0005)。结论前列腺癌根治术后^(68)Ga-PSMA-11 PET/CT延迟显像可以探测更多更小的盆腔复发病灶。

Objective To analyze the value of^(68)Ga-Prostate-specific membrane antigen(PSMA)-11 PET/CT delayed imaging in the detection of pelvic recurrence after radical prostatectomy.Methods Twenty-four patients who underwent radical prostatectomy at our institution were retrospectively enrolled in the study.The patients received^(68)Ga-PSMA-11 PET/CT whole-body standard imaging at 60 min and pelvic delayed imaging at 180 min after intravenous injection of radiopharmaceutical.The number,size,maximum standard uptake(SUVmax)and target-to-background ratio(T/B)of pelvic recurrent lesions were compared between standard imaging and delayed imaging.Results Pelvic recurrence occurred in 17 of the 24 patients.Of the recurrent patients,standard imaging was positive in 15 cases and delayed imaging was positive in 17 cases.There were 7 cases without recurrence,and both standard imaging and delayed imaging were negative.There was no statistical difference(χ^(2)=2.125,P=0.145)in the sensitivity of detecting pelvic recurrence between standard imaging(82.24%,15/17)and delayed imaging(100.00%,17/17).Delayed imaging detected 10 more pelvic positive lesions than standard imaging.The diameter 4(3,8)mm of additional pelvic lesion detected by delayed imaging was smaller than that 8(7,12)mm of pelvic lesion detected by standard imaging(U=94,P=0.004).The SUVmax 10.08(6.58,15.50)of delayed imaging was similar to that of standard imaging 7.89(4.87,15.26)(U=1204,P=0.234),however the T/B value of delayed imaging 55.90(30.45,109.27)was significantly higher than that of standard imaging 32.89(21.67,55.07)(U=840,P=0.0005).Conclusion^(68)Ga-PSMA-11 PET/CT delayed imaging can detect more and smaller pelvic recurrent lesions after radical prostatectomy.