磁珠肺小结节定位技术的动物实验研究

Localization of small pulmonary nodules with magnetic beads: An animal experiment

目的探讨应用磁珠对肺小结节进行定位的可行性。方法取新西兰兔12只,随机分为两组,每组6只,麻醉后一组开胸在直视下穿刺,另一组在X线引导下进行经皮穿刺,均在肺部不同部位假想肺小结节并注射1个和2个直径1 mm、高为3 mm的圆柱形示踪磁体(磁珠),以直径9 mm、高19 mm的寻踪磁体吸引磁珠所在部位,根据吸引情况判断对结节的定位效果。结果 12只兔定位均操作成功,磁珠注射部位的肺组织微量出血,无血肿形成,注射1个磁珠进行定位在应用寻踪磁体探寻时有1例发生磁珠脱出现象,同时注射2个磁珠进行定位,未出现磁珠移位及脱出现象。结论初步验证了应用磁珠对肺小结节进行定位是可行的,其操作简单,成本低,可以缩短手术时间。

Objective To investigate the feasibility of using magnetic beads to locate small pulmonary nodules.Methods Twelve rabbits were randomly divided into two groups, 6 in each group. One group underwent thoracotomy after anesthesia and the other group underwent percutaneous puncture under the guidance of X-ray. One and two cylindrical tracer magnets(magnetic beads) with a diameter of 1 mm and a height of 3 mm were injected adjacent to the imaginary pulmonary nodules in left lung in each group. The magnetic beads beside the imaginary nodules were attracted by a pursuit magnet with a diameter of 9 mm and a height of 19 mm. The effectiveness of localization by magnetic beads were determined by attraction between tracer and pursuit magnets. Results All processes were uneven in 12 rabbits.There was micro hemorrhage and no hematoma in the lung tissue at the injection site of the magnetic beads. When tracked with the pursuit magnets, there was one bead divorce in cases that one bead was injected, but no migration or divorce of the magnetic beads in cases that two magnetic beads were simultaneously injected to localize the small pulmonary nodules. Conclusion The feasibility of using magnetic beads to locate small pulmonary nodules has been preliminarily verified.