Hippo通路与肺高血压的关系

Internal relationship between Hippo pathway and pulmonary hypertension

肺高血压是一类进展性的肺血管疾病,存在血管过度收缩和肺血管异常重塑,肺动脉压力逐渐增加,最终导致右心室衰竭甚至死亡。肺高血压的发病机制目前尚不确切,但有研究表明肺高血压的发生发展过程存在Hippo通路或Hippo通路的某些组成成分的参与。本文将对Hippo通路或Hippo通路的某些组成成分在肺高血压发生发展过程中的相关研究作简要综述。

Pulmonary hypertension is a kind of progressive pulmonary vascular diseases in which there is excessive vasoconstriction and abnormal pulmonary vascular remodeling, and then a gradual increase in pulmonary arterial pressure, and it eventually leads to right ventricular failure and even death. The pathogenesis of pulmonary hypertension is still uncertain, but some studies suggest that Hippo pathway or some components of the Hippo pathway may be involved in the progress of pulmonary hypertension. In this review, we describe the mechanism of the Hippo pathway or some components of the Hippo pathway in the progress of pulmonary hypertension.