慢性肾脏病血管钙化研究进展

Updates on vascular calcification in chronic kidney disease

心血管疾病(CVD)是导致慢性肾脏病(CKD)患者死亡的最常见原因。血管钙化可以造成患者的CVD患病率升高,CKD患者的血管钙化是一种由矿物质代谢异常、激素水平改变、细胞信号通路异常激活、表观遗传学调控等引起的复杂的生理过程。本文综述了CKD患者血管钙化的特点、机制、影响因素等方面的研究进展。

Cardiovascular disease(CVD)is the most commom factor for death in patients with chronic kidney disease(CKD).Vascular calcification could promote the morbidty of CVD.Vascular calcification of patients with CKD is a complex biological process which is mediated by the dysregulated form of matrix mineral metabolism,change of hormones,epigenetic regulation and the activation of cellular signaling pathways.This paper reviewed the characteristics,physiological mechanism,influence factors of vascular calcificationin in patients with CKD.