垂体后叶素与卡前列素氨丁三醇联合用药方案治疗胎盘早剥产后大出血的临床分析

Clinical analysis of the combination regimen of pituitrin and carboprost tromethamine in the treatment of postpartum hemorrhage after placental abruption

目的探究垂体后叶素与卡前列素氨丁三醇联合用药方案治疗胎盘早剥产后大出血的临床效果及对妊娠结局的影响。方法94例胎盘早剥产后大出血产妇为研究对象,依据随机数字表法分为对照组和观察组,每组47例。对照组产妇接受卡前列素氨丁三醇治疗方案,观察组采用垂体后叶素与卡前列素氨丁三醇联合用药方案。对比两组产妇的第三产程时间、止血时间、产后不同时间段累计出血量及不良妊娠结局发生情况。结果观察组第三产程时间(4.85±0.47)min、止血时间(19.27±1.81)min均短于对照组的(8.46±0.83)、(29.53±2.84)min,差异有统计学意义(P<0.05)。观察组产后10 min、30 min、2 h、24 h累计出血量均少于对照组,差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率8.51%低于对照组的42.55%,差异有统计学意义(P<0.05)。结论应用垂体后叶素与卡前列素氨丁三醇联合用药方案治疗胎盘早剥产后大出血效果显著,能有效缩短出血时间,降低出血量,从而改善产妇的妊娠结局。

Objective To investigate the clinical effect of the combination regimen of pituitrin and carboprost tromethamine in the treatment of postpartum hemorrhage after placental abruption,and its influence on pregnancy outcome.Methods A total of 94 cases with postpartum hemorrhage after placental abruption were selected as the research subjects,and all were randomly divided into a control group and an observation group according to the random numerical table,with 47 cases in each group.The control group adopted carboprost tromethamine treatment,and the observation group adopted the combination of pituitrin and carboprost tromethamine.The time of the third stage of labor,hemostasis time,cumulative blood loss in different time periods after delivery,and the occurrence of adverse pregnancy outcomes were compared between the two groups.Results The time of the third stage of labor(4.85±0.47)min and hemostasis time(19.27±1.81)min in the observation group were shorter than(8.46±0.83)and(29.53±2.84)min in the control group,and the difference was statistically significant(P<0.05).The cumulative blood loss of the observation group at 10 min,30 min,2 h,and 24 h after delivery was less than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 8.51%,which was lower than 42.55%in the control group,and the difference was statistically significant(P<0.05).Conclusion Combination regimen of pituitrin and carboprost tromethamine has significant effect on the treatment of postpartum hemorrhage after placental abruption,and it can effectively shorten the bleeding time and reduce the amount of blood loss,so as to improve the pregnancy outcome of pregnant women.