丁苯酞软胶囊治疗脑梗死后血管性痴呆的疗效观察

Efficacy of butylphthalide soft capsule on vascular dementia after cerebral infarction

目的分析脑梗死后血管性痴呆(VD)应用丁苯酞软胶囊治疗的疗效。方法80例脑梗死后VD患者,按照入院先后顺序分为对照组和观察组,每组40例。对照组患者采取尼莫地平治疗,观察组患者采取丁苯酞软胶囊治疗。比较两组患者的临床疗效、不良反应发生情况及治疗前后神经功能缺损程度、认知功能、日常生活能力、总体健康。结果观察组患者治疗总有效率97.50%高于对照组的80.00%,不良反应发生率10.00%低于对照组的35.00%,差异具有统计学意义(P<0.05)。治疗前,两组患者美国国立卫生研究院卒中量表(NIHSS)评分、蒙特利尔认知评估量表(MoCA)评分、日常生活活动能力量表(ADL)评分、健康调查简表(SF-36)评分比较差异无统计学意义(P>0.05);治疗后,观察组患者NIHSS评分低于对照组,MoCA评分、ADL评分、SF-36评分高于对照组,差异具有统计学意义(P<0.05)。结论与尼莫地平比较,丁苯酞软胶囊治疗脑梗死后VD具有更高的安全性和有效性,能够促进患者尽快康复,值得临床推广应用。

Objective To analyze the efficacy of butylphthalide soft capsule on vascular dementia(VD)after cerebral infarction.Methods A total of 80 patients with VD after cerebral infarction were divided into a control group and an observation group according to the order of admission,with 40 cases in each group.Patients in the control group were treated with nimodipine,and patients in the observation group were treated with butylphthalide soft capsules.The clinical efficacy,occurrence of adverse reactions,and degree of neurological deficit,cognitive function,activities of daily living and general health before and after treatment of the two groups were compared.Results The total effective rate 97.50%of the observation group was higher than 80.00%of the control group,and the incidence of adverse reactions 10.00%was lower than 35.00%of the control group.All the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the National Institutes of Health stroke scale(NIHSS)scores,Montreal cognitive assessment(MoCA)scores,activities of daily living(ADL)scores,and 36-item short-form health survey(SF-36)scores between the two groups(P>0.05).After treatment,the NIHSS score of the observation group was lower than that of the control group,and the MoCA score,ADL score,and SF-36 score were higher than those of the control group.All the difference was statistically significant(P<0.05).Conclusion Compared with nimodipine,butylphthalide soft capsules are safer and more effective in treating VD after cerebral infarction,and it can promote the early recovery of patients,which is worthy of clinical promotion and application.