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曲美布汀联合莫沙必利治疗功能性消化不良的效果 被引量:1

Effect of trimebutine combined with mosapride in the treatment of functional dyspepsia
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摘要 目的探索曲美布汀联合莫沙必利治疗功能性消化不良的效果。方法80例功能性消化不良患者,通过摸球分为对照组(奇数)与观察组(偶数),每组40例。对照组实施曲美布汀治疗,观察组实施曲美布汀联合莫沙必利治疗。比较两组患者治疗前后的血浆胃动素、P物质以及胃电图监测结果、治疗效果。结果治疗后,观察组患者血浆胃动素(282.26±43.27)pmol/L、P物质(42.46±5.18)pmol/L均高于对照组的(249.18±36.31)、(30.18±4.17)pmol/L,差异均具有统计学意义(P<0.05)。治疗后,观察组患者胃电频次(3.01±0.28)次/min、胃电节律紊乱百分比(11.24±2.19)%均低于对照组的(3.98±0.71)次/min、(14.54±1.18)%,慢波百分比(71.16±6.31)%高于对照组的(60.75±4.49)%,差异均具有统计学意义(P<0.05)。观察组治疗总有效率为100.00%高于对照组的77.50%,差异具有统计学意义(P<0.05)。结论曲美布汀联合莫沙必利治疗方案对改善患者胃功能具有非常明显的作用,治疗效果更加理想,值得推广使用。 Objective To investigate the effect of trimebutine combined with mosapride in the treatment of functional dyspepsia.Methods A total of 80 patients with functional dyspepsia were divided into a control group(odd number)and an observation group(even number)according to ball-touching method,with 40 cases in each group.The control group was treated with trimebutine,and the observation group was treated with trimebutine and mosapride.The plasma motilin and substance P levels before and after treatment,electrogastrogram monitoring results and therapeutic effect were compared between the two groups.Results After treatment,the plasma motilin(282.26±43.27)pmol/L and substance P(42.46±5.18)pmol/L in the observation group were higher than(249.18±36.31)and(30.18±4.17)pmol/L in the control group,and the differences were statistically significant(P<0.05).After treatment,the frequency of gastric electricity(3.01±0.28)times/min and the percentage of gastric rhythm disorder(11.24±2.19)%in the observation group were lower than(3.98±0.71)times/min and(14.54±1.18)%in the control group,and the percentage of slow wave(71.16±6.31)%was higher than(60.75±4.49)%in the control group.All the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 100.00%,which was higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of trimebutine and mosapride has a very obvious effect on improving the gastric function of patients,and the therapeutic effect is more ideal,which is worthy of promotion and application.
作者 郑娜 ZHENG Na(Tiexi Branch of Shenyang Emergency Center,Shenyang 110020,China)
出处 《中国现代药物应用》 2021年第18期126-128,共3页 Chinese Journal of Modern Drug Application
关键词 曲美布汀 莫沙必利 功能性消化不良 治疗效果 Trimebutin Mosapride Functional dyspepsia Therapeutic effect
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