急性冠脉综合征经PCI治疗后维持性服用替格瑞洛对患者血小板功能、心率变异性及安全性的影响

Effects of maintenance administration of ticagrelor on platelet function,heart rate variability and safety in patients with acute coronary syndrome after PCI

目的观察急性冠脉综合征(ACS)患者采用经皮冠状动脉介入术(PCI)后维持性服用替格瑞洛对血小板功能、心率变异性及安全性的影响。方法回顾性分析我院接收的96例ACS患者的资料,按治疗方案将其分为对照组和观察组,各48例。两组均择期行PCI术,对照组术后给予氯吡格雷治疗,观察组术后给予替格瑞洛治疗。比较两组的治疗效果。结果治疗后,观察组的血小板功能(MPAR、PRU、CD62p)、心率变异性(SDNN、SDANN、LF、HF)均优于对照组(P<0.05)。观察组的MACE、出血事件总发生率低于对照组(P<0.05)。结论ACS患者在PCI术后维持性应用替格瑞洛可改善血小板功能和心率变异性,减少MACE和出血事件。

Objective To observe the effects of maintenance administration of ticagrelor on platelet function,heart rate variability and safety in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods The data of 96 patients with ACS enrolled in our hospital were analyzed retrospectively.The patients were divided into control group and observation group according to the treatment plan,with 48 cases in each group.Elective PCI was performed in both groups.The control group was treated with clopidogrel,and the observation group was treated with ticagrelor after PCI.The therapeutic effects of the two groups were compared.Results After treatment,the platelet function(MPAR、PRU、CD62p)and heart rate variability(SDNN,SDANN,LF,HF)in the observation group were better than those in the control group(P<0.05).The total incidence of MACE and bleeding events in the observation group were lower than those in the control group(P<0.05).Conclusion Maintenance application of ticagrelor in patients with ACS after PCI can improve platelet function and heart rate variability,reduce MACE and bleeding events.