针刺疗法结合疏肝解郁法治疗肝气郁结型脑卒中后认知障碍的效果及对神经递质水平的影响

Effect of acupuncture therapy combined with dispersing the depressed liver-energy in the treatment of post-stroke cognitive impairment of liver-Qi stagnation type and its influence on neurotransmitter level

目的探讨针刺疗法结合疏肝解郁法治疗肝气郁结型脑卒中后认知障碍的效果及对神经递质水平的影响。方法选取2019年2月至2020年5月收治的80例肝气郁结型脑卒中后认知障碍患者为研究对象,采用随机数字表法将其分为对照组与观察组,每组40例。对照自采用常规药物联合针刺疗法,观察组在对照组基础上加用疏肝解郁法,比较两组的治疗效果。结果治疗后,两组的MoCA、RBMT评分均升高,且观察组高于对照组(P<0.05)。治疗后,两组的miR-132、miR-135表达均升高,且观察组高于对照组(P<0.05)。治疗后,两组的5-HT、DA、NE水平均升高,且观察组高于对照组(P<0.05)。结论针刺疗法结合疏肝解郁法治疗肝气郁结型脑卒中后认知障碍的效果满意,可调节miR-132、miR-135与神经递质水平,值得推广。

Objective To explore the effect of acupuncture therapy combined with dispersing the depressed liver-energy in the treatment of post-stroke cognitive impairment of liver-Qi stagnation type and its influence on neurotransmitter level.Methods A total of 80 patients with post-stroke cognitive impairment of liver-Qi stagnation type treated from February 2019 to May 2020 were selected as the research objects and divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with conventional drugs combined with acupuncture therapy,and the observation group was treated with dispersing the depressed liver-energy on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,MoCA and RBMT scores in both groups increased,and those in the observation group were higher than the control group(P<0.05).After treatment,the expressions of miR-132 and miR-135 in both groups increased,and those in the observation group were higher than the control group(P<0.05).After treatment,the levels of 5-HT,DA and NE in both groups increased,and those in the observation group were higher than the control group(P<0.05).Conclusion Acupuncture therapy combined with dispersing the depressed liver-energy in the treatment of post-stroke cognitive impairment of liver-Qi stagnation type has a satisfactory effect,it can regulate miR-132,miR-135 and neurotransmitter levels,which is worthy of promotion.