基于肠道菌群探讨抑郁症机制的研究进展

Research Progress in Mechanism of Depression from Perspective of Gut Microbiota

肠道菌群有“第二大脑”之称,在肠道和大脑的相互作用中发挥重要作用,可以通过下丘脑-垂体-肾上腺轴、神经免疫系统以及各种代谢过程影响机体大脑功能。抑郁症是以情绪低落、兴趣缺乏、失眠、易焦虑等为主要临床症状的心理疾病。近年来,抑郁症的发病率和危害性逐渐上升,严重危害人类身心健康,给社会造成巨大的经济损失,其病因复杂多样,除遗传和环境因素外,肠道菌群异常也是抑郁症的病因之一,肠道菌群失调可能会影响抑郁症的发生发展,但其作用机制尚不清楚。未来,可将肠道菌群作为靶点,并联合现有传统治疗手段,不断丰富抑郁症的治疗。

Known as the"second brain",the gut microbiota plays an important role in the interaction between the gut and brain.It can affect the body's brain function through the hypothalamic-pituitary-adrenal axis,the neuroimmune system and various metabolic processes.Depression is a psychological disease with low mood,lack of interest,insomnia,anxiety etc.as major clinical symptoms.In recent years,the incidence and harm of depression have been gradually increasing,which seriously endangers human physical and mental health,and causes huge economic losses to the society.The etiology is complex and diverse:in addition to genetic and environmental factors,abnormal intestinal flora is also one of the causes of depression.The gut microbiota imbalance may affect the onset and progress of depression,but the mechanism remains to be explored.In the future,it is possible to enrich the treatment of depression with intestinal flora as the target,and in combination with traditional treatment methods.