一线化疗失败后的晚期非小细胞肺癌治疗进展

Treatment Progress of Advanced Non-small Cell Lung Cancer after Failure of First-line Chemotherapy

肺癌的发病率和死亡率较高,大多起病隐匿,大部分患者确诊时已为晚期,错失手术机会,因此化疗为晚期非小细胞肺癌(NSCLC)最主要的治疗手段。但晚期NSCLC的一线化疗效果并不理想,二线化疗应用率则明显降低,且不良反应进一步加重,靶向与免疫治疗也因其选择性而在临床应用受限。中医药治疗方案以辨证论治为理论指导,治疗晚期NSCLC的临床疗效显著。因此,将中医药与现代医学有机结合并形成综合诊疗方案,可为晚期NSCLC的临床治疗提供更为有效的方案选择。

The incidence and mortality of lung cancer are high,and most of the lung cancer has insidious onset,so most of the patients are in advanced stage when diagnosed and have lost the opportunity of operation.Therefore,chemotherapy is the most important treatment for advanced non-small cell lung cancer(NSCLC).But the effect of first-line chemotherapy for advanced NSCLC is not ideal,while the application rate of second-line chemotherapy is significantly reduced,and the adverse effects are further aggravated.Targeted therapy and immunotherapy are also limited in clinical application because of their selectivity.The traditional Chinese medicine treatment is guided by the theory of syndrome differentiation and treatment,and the clinical efficacy of the treatment of advanced NSCLC is significant.Therefore,the organic combination of traditional Chinese medicine and modern medicine to form a comprehensive diagnosis and treatment scheme can provide more effective selections for the clinical treatment of advanced NSCLC.