“非指南理想运动”与红肉摄入过多对高血压和2型糖尿病的交互作用研究

The Interaction among“Non-Guide Ideal Exercise”and Excessive Red Meat Intake on Hypertension and Type 2 Diabetes

目的:探讨“非指南理想运动”和红肉摄入过多对高血压、2型糖尿病的影响并分析交互作用强度。方法:2018年7—11月采用多阶段整群随机抽样法抽取巢湖市2885名常住成年(年龄≥18岁)居民进行问卷调查、体格检查和实验室检测,运用多分类逻辑回归(multinomiallogisticregression,MLR)分析交互作用,采用相对超额危险度(RERI)、归因比(AP)和交互作用指数(S)评价交互作用。结果:“非指南理想运动”者、红肉摄入过多者的高血压和2型糖尿病患病率均高于“指南理想运动”者和红肉摄入适量者(P<0.001)。调整混杂因素后,与“指南理想运动”且红肉摄入适量者相比,“非指南理想运动”且红肉摄入过多者高血压(OR=10.07,95%CI:7.33,13.83)、2型糖尿病(OR=10.87,95%CI:7.20,16.42)患病率最高。“非指南理想运动”与红肉摄入过多对高血压的相加交互作用指标分别为RERI=4.10(95%CI:1.64,6.56),AP=0.41(95%CI:0.24,0.58),S=1.82(95%CI:1.30,2.56);对2型糖尿病分别为:EREI=4.88(95%CI:1.61,8.16),AP=0.45(95%CI:0.23,0.66),S=1.98(95%CI:1.24,3.15)。结论:“非指南理想运动”与红肉摄入过多与高血压、2型糖尿病患病率均正向关联,且对高血压、2型糖尿病均存在相加交互协同作用。

Objective:To investigate the effect of“non-guide ideal exercise”and excessive red meat intake on hypertension and type 2 diabetes and to analyze the interaction intensity.Meth‐ods:The multi-stage cluster random sampling method was used to extract 2885 Chaohu City adult permanent resident aged 18 and from July to November 2018.All the adults would accept the questionnaire,physical examination and laboratory tests.Multinomial logistic regression(MLR)was used to analyze the interaction.The relative excess risk due to interaction(RERI),the attributable proportion due to interaction(AP)and the synergy index(S)were used to assess the additive interactions.Results:The prevalence of hypertension and type 2 diabete in residents of“non-guide ideal exercise”and excessive red meat intake were higher than those of“guide ideal exercise”and moderate red meat intake(both P<0.001).After adjusting for confounders,the risk of hypertension(OR=10.07,95%CI:7.33,13.83)and type 2 diabetes(OR=10.87,95%CI:7.20,16.42)were highest in the group with“non-guide ideal exercise”and excessive red meat intake compared with those with“guide ideal exercise”and moderate red meat intake.The additive interaction indexes of“non-guide ideal exercise”and excessive red meat intake for hy‐pertension were RERI=4.10(95%CI:1.64,6.56),AP=0.41(95%CI:0.24,0.58),S=1.82(95%CI:1.30,2.56)respectively;and for type 2 diabetes were EREI=4.88(95%CI:1.61,8.16),AP=0.45(95%CI:0.23,0.66),S=1.98(95%CI:1.24,3.15)respectively.Conclusions:The“non-guide ideal exercise”and excessive red meat intake were positively correlated with hyperten‐sion and type 2 diabetes prevalence,and there was an additive interactive synergistic effect on hypertension and type 2 diabetes.