从“糖毒损络”角度初探糖尿病足发病机制与特点

Preliminary study on the pathogenesis and characteristics of diabetic foot from the perspective of"sugar toxin damage collaterals"

现代医学研究发现,糖尿病足是主要以高血糖状态引起的机体代谢紊乱导致血管和神经损伤为主而发生足部感染、溃疡和/或深层组织破坏的疾病状态。高血糖状态属于中医学新兴概念之“糖毒”,具有耗伤脏腑、经络气血的特点。络病理论是中医认识疾病的重要理论,有学者提出“脉络—血管系统病”的新概念。通过长期临床观察并结合文献研究发现,糖尿病足的发生发展过程与“糖毒损络”致病的特点高度相似,故将其发病机制总结归纳为先天或后天等各种因素导致机体脏腑功能受损的基础上,糖毒内生,耗伤气阴,络脉虚滞,痹阻不通,肢末失养而发为本病。

Modern medical research has found that diabetic foot is a disease state in which the body's metabolic disorder caused by high blood sugar state causes blood vessel and nerve damage,and foot infection,ulcers and/or deep tissue destruction occur.The state of hyperglycemia belongs to the new concept of"sugar toxin"in traditional Chinese medicine,which has the characteristics of damaging the viscera and meridian qi and blood.The theory of collateral disease is an important theory for the understanding of diseases in Chinese medicine.Some scholars have put forward a new concept of"disorders of the veins and vascular system".Through long-term clinical observation and literature research,it is found that the occurrence and development process of diabetic foot is highly similar to the pathogenesis of"glycotoxic collateral damage."On the basis of damage,sugar toxin is endogenous,depletion of Qi and Yin,deficiency of collaterals,obstruction of arthralgia,loss of nourishment at the end of the limbs and the disease.