2型糖尿病患者心脑血管并发症与平均血小板体积的相关性

Correlation between Cardio-cerebrovascular Complications and Mean Platelet Volume in Patients with Type 2 Diabetes Mellitus

目的探讨2型糖尿病(T2DM)合并心脑血管并发症与平均血小板体积(MPV)的关系。方法选取T2DM患者283例,分为单纯T2DM组122例和T2DM合并心脑血管并发症(T2DM+CCVD)组161例,对2组患者一般资料和各生化指标进行分析。结果T2DM+CCVD组患者年龄、病程、BMI、SBP均大于T2DM组,hs-CRP、FPG、TC、TG、LDL-C、SUA、HbA1C、MPV均高于T2DM组,HDL-C低于T2DM组;Pearson相关分析显示T2DM合并心脑血管并发症患者MPV与病程、HDL-C、PDW呈正相关,与TG呈负相关。回归分析显示:病程、SBP、MPV是T2DM患者发生心脑血管并发症的危险因素,HDL-C是其保护因素,且PDW、HDL-C、LDL-C是MPV的独立影响因素。结论MPV在T2DM合并心脑血管并发症中显著升高,是T2DM患者发生心脑血管并发症的危险因素。

Objective To investigate the relationship between cardio-cerebrovascular complications and mean platelet volume(MPV)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 283 T2DM patients were selected.They were divided into T2DM group(n=122)and(T2DM+CCVD)group(n=161).General information and the biochemical indexes of each group were analyzed.Results Compared with the T2DM group,age,course of disease,BMI,SBP,hS-CRP,FPG,TC,TG,LDL-C,SUA,HbA1 c and MPV were all higher in T2DM+CCVD group,while HDL-C was lower than that in T2DM group.Pearson correlation analysis showed that MPV was positively correlated with course of disease,HDL-C and PDW,and negatively correlated with TG in patients with type 2 diabetes mellitus with cardio-cerebrovascular complications.Regression analysis showed that:the course of the disease,SBP,MPV were risk factors for cardio-cerebrovascular complications in type 2 diabetes,HDL-C is its protection factor,PDW,HDL-C and LDL-C were independent influencing factors of MPV.Conclusion MPV was significantly increased in T2DM+CCVD group,and may be a risk factor for CCVD in T2DM patients.