运动锻炼对抑郁症女性患者干预效果及对其血清雌激素水平的影响

Intervention effect of exercise on female patients with depression and its influence on serum estrogen level

目的研究运动锻炼对抑郁症女性患者的治疗效果,以及其对患者血清雌激素水平的影响。方法前瞻性纳入2018年1月到2020年12月在青海省第三人民医院接受治疗的轻中度抑郁症女性患者104例,按照随机数表法均分为抑郁对照组52例和运动锻炼组52例,并在同期招募52例健康女性作为正常对照组。正常对照组不接受任何治疗,抑郁对照组接受常规心理治疗,运动锻炼组在常规心理治疗的基础上进行为期3个月的运动锻炼。治疗前后,通过抑郁筛选量表(CES-D)、抑郁自评量表(SDS)和90项症状清单(SCL-90)评估3组研究对象抑郁情况,并检测3组研究对象血清对5-羟色胺(5-HT)、去甲肾上腺素(NE)、皮质醇、雌二醇和促卵泡激素(FSH)。结果治疗前,抑郁对照组和运动锻炼组患者CES-D、SDS及SCL-90评分均显著高于正常对照组,血清5-HT、NE和雌二醇均显著低于正常对照组,而血清皮质醇和FSH均显著高于正常对照组,差异均有统计学意义(P<0.05);而抑郁对照组和运动锻炼组间比较,差异无统计学意义(P>0.05)。治疗后,运动锻炼组患者CES-D、SDS及SCL-90评分均显著低于抑郁对照组,血清5-HT、NE和雌二醇均显著高于抑郁对照组,而血清皮质醇和FSH均显著低于抑郁对照组,差异均有统计学意义(P<0.05)。结论运动锻炼可以显著改善抑郁女性患者抑郁病情,并且可以改善患者雌激素水平。

Objective To study the therapeutic effect of exercise on female patients with depression and its effect on the serum estrogen level of patients.Methods A total of 104 female patients with mild to moderate depression who were treated in our hospital from January 2018 to December 2020 were included.They were divided into the depression control group 52 cases and the exercise group 52 cases according random number table method,and 52 healthy women were recruited as normal control group during the same period.The normal control group did not receive any treatment,the depression control group received conventional psychotherapy,and the exercise group received 3 months of exercise on the basis of conventional psychotherapy.Before and after treatment,we used the Center for Epidemiological Survey,Depression Scale(CES-D),Self-Rating Depression Scale(SDS)and Symptom Checklist 90(SCL-90)to assess the depression of each group of subjects,and test each group of subjects Serum levels of 5-hydroxytryptamine(5-HT),norepinephrine(NE),cortisol,estradiol(E2)and follicle stimulating hormone(FSH).Results The scores of CES-D,SDS and SCL-90 of depressed patients were significantly higher than those of the normal control group(P<0.05).The serum 5-HT,NE and E2 were significantly lower than those of the normal control group,while the serum cortisol and FSH were significantly higher.Compared with the normal control group,the differences were statistically significant(P<0.05);while there was no significant difference between the depression control group and the exercise group(P>0.05).After exercise,the scores of CES-D,SDS and SCL-90 in the exercise group were significantly lower than those in the depression control group,serum 5-HT,NE and E2 were significantly higher than those in the depression control group,while the serum cortisol and FSH were significantly lower than the depression control group,the differences were statistically significant(P<0.05).Conclusion Exercise can significantly improve the depression of depressed female patients,and can improve the level of estrogen in patients.