女性闭经后萎缩性尿道炎患者检测血清促卵泡素、黄体生成素和垂体泌乳素的临床价值

Clinical value of serum follicle stimulating hormone,luteinizing hormone and pituitary prolactin were measured in women with atrophic urethritis after amenorrhea

目的研究女性闭经后萎缩性尿道炎患者检测血清促卵泡素(FSH)、黄体生成素(LH)、垂体泌乳素(PRL)的临床意义。方法采用回顾性分析方法,研究对象为2019年1月至2020年1月入院的42例闭经后萎缩性尿道炎患者与42名闭经后经体检确诊无萎缩性尿道炎的健康女性,分别将其设为研究组与对照组,两组均选用放射免疫分析法检测血清FSH、LH、PRL、睾酮(T)、孕酮(P)及雌二醇(E2)水平,检测完成后比较两组各项血清指标水平。结果研究组患者血清FSH、LH及PRL水平分别为(13.17±3.12)mU/mL、(14.33±3.14)mU/mL、(41.15±6.38)ng/mL,明显高于对照组[(6.25±1.63)mU/mL、(4.47±1.01)mU/mL、(15.24±4.83)ng/mL],血清E2水平为(41.23±15.31)pg/mL,明显低于对照组[(51.37±8.82)pg/mL],差异均有统计学意义(P<0.05);两组患者血清T、P水平比较,差异无统计学意义(P>0.05)。结论女性闭经后萎缩性尿道炎与血清FSH、LH及PRL水平密切相关,可作为临床诊断女性闭经后萎缩性尿道炎的参考依据。

Objective To study the clinical significance of detecting serum follicle stimulating hormone(FSH),luteinizing hormone(LH)and pituitary prolactin(PRL)in female patients with atrophic urethritis after amenorrhea.Methods The retrospective analysis methods was used and the subjects of the study were 42 patients with post-menopausal atrophic urethritis admitted to Dalian Maternal and Child Health Care Hospital from January 2019 to January 2020 and 42 healthy women with no atrophic urethritis confirmed by physical examination after menopause.The levels of serum FSH,LH,PRL,testosterone(T),progesterone(P)and estradiol(E2)in the two groups were detected by radioimmunoassay.After the detection was completed,the serum levels of the two groups were compared.Results The serum FSH,LH and PRL levels of patients in the study group were(13.17±3.12)mU/mL,(14.33±3.14)mU/mL,(41.15±6.38)ng/mL,which were significantly higher than those in the control group[(6.25±1.63)mU/mL,(4.47±1.01)mU/mL,(15.24±4.83)ng/mL],and the difference was significant(P<0.05).The serum E2 level of the study group was(41.23±15.31)pg/mL,which was significantly lower than that of the control group[(51.37±8.82)pg/mL],and the difference was significant(P<0.05);there was no significant difference between the two groups of patients'serum T and P levels(P>0.05).Conclusion Atrophic urethritis in women after amenorrhea is closely related to serum FSH,LH and PRL levels,which can be used as a reference for clinical diagnosis of atrophic urethritis in women after amenorrhea.