低密度脂蛋白受体相关蛋白6的功能及其在疾病研究中的进展

The research progress on function of low density lipoprotein receptor-related protein 6 and its related diseases

低密度脂蛋白受体相关蛋白6是经典Wnt信号通路的重要受体蛋白之一。该蛋白编码基因的突变与人类多种疾病相关,包括代谢综合征、肿瘤、阿尔兹海默症以及骨质疏松症等。低密度脂蛋白受体相关蛋白6的突变基因形式在临床诊断中亦具有重要的指导意义。本文将围绕低密度脂蛋白受体相关蛋白6的功能及其相关疾病作一综述。

The low density lipoprotein receptor-related protein 6(LRP6)is one of the important receptor proteins that perform the canonical Wnt/β-catenin pathway.Mutations in the protein are often associated with a variety of human diseases,including metabolic syndrome,tumor,Alzheimer's disease and osteoporosis.The mutation of low-density lipoprotein receptor-related protein 6 will have important guiding significance in the clinical diagnosis.In this paper,the function of low-density lipoprotein receptor-related protein 6 and the occurrence and development of related diseases will be summarized to provide useful resources for future research.