MicroRNA通过肠道菌群对绝经后骨质疏松症影响的机制探讨

The regulatory mechanism of microRNA regulating intestinal flora in postmenopausal osteoporosis

胃肠道是营养和矿物质高效吸收的重要部位。研究显示胃肠道微生物群通过肠-骨轴对骨质量具有调节作用,其作用机制十分复杂,主要通过矿物质吸收、激素控制和免疫调节来实现。中药可以调节肠道菌群,起到治疗绝经后骨质疏松症的作用。近期研究发现,microRNA通过调节肠道微生物基因,改变肠道微生物的生理功能,从而调节骨代谢,影响绝经后骨质疏松症的发生与发展。本文就microRNA调节肠道菌群的研究现状作一综述,探讨绝经后骨质疏松症的调节机制,为绝经后骨质疏松症的肠道微生态研究提供一定的理论依据。

Gastrointestinal tract is an important part of gastrointestinal tract for efficient absorption of nutrients and minerals. Research showed that gastrointestinal tract microbiota can regulate bone quality through gut-bone axis.The mechanism of act is very complex, which is mainly achieved through mineral absorption, hormone control and immune regulation. Traditional Chinese medicine can adjust the intestinal flora and play a role in the treatment of postmenopausal osteoporosis.Recent studies have found that microRNA changes the physiological functions of intestinal microorganisms by regulating intestinal microbial genes, thereby regulating bone metabolism and affecting the occurrence and development of postmenopausal osteoporosis.In this paper, the current status of research on the regulatory effect of microRNA on intestinal flora was reviewed in detail, and the mechanism of the regulation on postmenopausal osteoporosis was discussed, so as to provide theoretical basis for the research on intestinal microecology in postmenopausal osteoporosis.