电针刺激双侧率谷穴脑激活效应fMRI研究

The brain areas activity of electroacupuncture stimulation at the bilateral Shuaigu:a fMRI study

目的:采用血氧水平依赖功能磁共振成像(BOLD-fMRI)技术,探讨电针刺激双侧率谷穴(GB8)即刻脑效应。方法:招募15例健康受试者,采用针刺专用头颅线圈,针刺双侧率谷穴及非经非穴并进行fMRI扫描,采用SPM12软件进行预处理及统计学分析。采用REST软件提取激活脑区时间序列信号值,与各针感强度做相关性分析。结果:相比较非经非穴组,针刺双侧率谷穴后正激活脑区包括中脑导水管周围灰质、左侧眶部额下回、左侧海马旁回、右侧眶部额下回及右侧海马旁回,未见负激活脑区出现(P<0.05,FWEc校正)。中脑导水管周围灰质时间序列信号值与酸疼、胀满及麻木针感强度呈明显正相关(P<0.05)。结论:采用针刺专用头颅线圈观察针刺双侧率谷穴后即刻脑激活情况,可以为探讨头穴的针刺即刻脑效应机制提供一种方法。

Objective:To use the blood oxygen level-dependent functional magnetic resonance imaging(BOLD-fMRI)technique to explore the immediate brain areas activity of the bilateral Shuaigu(GB8)stimulated by electroacupuncture.Methods:Fifteen healthy subjects were recruited.Stimulation at bilateral Shuaigu and non-meridian non-acupoints using special acupuncture head coils,and fMRI scans were performed simultaneously.The SPM12 software was used to data preprocessing and the REST software was used to extract the time series signal values of the activated brain areas.The correlation between the time series signal value and the intensity of needle sense were statistical analyzed.Results:Compared with the non-meridian and non-acupoint group,the positive activated brain areas after stimulation at bilateral Shuaigu acupoints included periaqueductal gray matter,bilateral inferior frontal gyrus and bilateral parahippocampal gyrus,no negatively activated brain regions appeared(P<0.05,FWEc).The time series signal value of gray matter around the midbrain aqueduct was significantly positively correlated with the intensity of soreness,swelling and numbness(P<0.05).Conclusion:Special acupuncture scalp coils and fMRI study may provide a method for further exploring the mechanism of the immediate brain areas activity of scalp acupuncture.