线粒体靶向钙离子探针在心血管疾病中的应用

Applications of mitochondrial targeted calcium indicator in cardiovascular diseases

心血管疾病已成为引起人类死亡的主要原因,线粒体在心肌细胞和心血管疾病中起重要作用。线粒体是维持细胞能量代谢的重要细胞器,线粒体钙稳态失衡介导的线粒体损伤和功能障碍是众多疾病共同的病理生理机制。作为线粒体功能研究中的重要一环,线粒体靶向Ca^(2+)探针可特异性指示线粒体Ca^(2+)水平变化,对深化疾病状态下线粒体钙稳态失衡机制的研究具有重要意义。本文拟在不同心血管疾病中,对线粒体靶向Ca^(2+)探针的应用进行小结。

Cardiovascular disease is one of the main causes of human death.Mitochondria is important to maintain the energy metabolism in myocardial cells and cardiovascular diseases.Dysfunction of mitochondrial calcium homeostasis could lead to many diseases.Mitochondrial targeted Ca^(2+) indicator can specifically indicate the mitochondrial Ca^(2+) level,which is significant for calcium homeostasis imbalance mechanism in diseases.In this review,the applications of mitochondrial targeted Ca^(2+) indicators in different cardiovascular diseases were summarized.