红细胞膜GLUT-1对葡萄糖及DHA转运机制的研究进展

Research progress on the transportation mechanism of glucose and DHA by erythrocyte membrane GLUT-1

红细胞结构和组成的特殊性使其更容易受到自由基的攻击而发生氧化损伤。除了红细胞内强大的抗氧化酶外,维生素C是红细胞内重要的非酶抗氧化物质。从食物中消化吸收的维生素C在血液中首先转变为脱氢抗坏血酸(dehydroascorbic acid,DHA),然后与葡萄糖共用红细胞膜葡萄糖转运蛋白1(glucose transporter-1,GLUT-1)而被转运入红细胞,在胞内DHA再被还原为维生素C发挥抗氧化损伤的作用。因此,研究红细胞膜GLUT-1对DHA与葡萄糖转运的精细调节,可以为糖尿病等相关疾病的预防、诊断和治疗提供新的思路。

The special structure and composition of erythrocyte make them more vulnerable to oxidative damage caused by free radical.In addition to the powerful enzymatic antioxidants,vitamin C is an important non-enzymatic antioxidant in erythrocytes.Vitamin C,which is digested and absorbed from food or drug,is first converted into dehydroascorbic acid(DHA)in the blood and then transported into erythrocytes by sharing the glucose transporter-1(GLUT-1)with glucose.After entering into erythrocytes,DHA is reduced to vitamin C to protect against oxidative damage.Therefore,studying the fine regulation of GLUT-1 on DHA and glucose transportation can provide new ideas for the prevention,diagnosis and treatment of diabetes and other related diseases.