高毒力肺炎克雷伯菌毒力因子研究进展

Research progress on virulence factors of hypervirulent Klebsiella pneumoniae

高毒力肺炎克雷伯菌是经典肺炎克雷伯菌的一种高毒力变异体,可在免疫功能健全宿主引起严重感染,具有致病性强、病死率高、预后差等特点。目前,高毒力肺炎克雷伯菌已经成为全球关注的重要病原体之一,给公共卫生安全和临床医疗带来重大挑战。本文就国内外有关高毒力肺炎克雷伯菌的荚膜多糖、铁载体、脂多糖和黏附素及新近发现的Ⅵ分泌系统等毒力因子进行阐述,有助于加深对该菌致病机制的理解与认识。

Hypervirulent Klebsiella pneumoniae,short for hvKP,is a hypervirulent variant of classical Klebsiella pneumoniae,which accounts for serious infection in healthy people,exhibits strong pathogenicity,high mortality and poor prognosis.At present,hvkp is of high prevalence all over the world,and the infection rate shows a continuous upward trend,which brings great challenges to public health security and clinical treatment.This paper summarized the research progress on virulence factors of hvkp,such as capsular polysaccharides,siderophore,lipopolysaccharide,adhesins and recently discovered TypeⅥsecreting system,and aimed to deepen the understanding and recognition of hvKP.