近10年动脉粥样硬化发病机制研究热点的可视化分析

Visualization Analysis of Research Hotspots of Atherosclerosis Pathogenesis in the Past 10 Years

目的分析近10年动脉粥样硬化发病机制的研究热点与趋势。方法检索2010年至2019年Web of Science核心合集数据库中SCI-E收录的关于动脉粥样硬化发病机制相关文献,应用CiteSpace软件对作者、国家、机构、学科进行共现分析,对作者、期刊进行共被引分析,对文献进行共被引、聚类及聚类时间线分析,对关键词进行共现及突现词分析。结果共纳入3320篇文献,近10年年发文量整体呈上升趋势;高产国家以美国、中国为主,主要研究机构为华盛顿大学等美国高校;高产作者为Weber C,且其文献被引量较高;研究学科以心血管系统与心脏病学为主;近10年研究的知识基础多集中在免疫与炎症等领域;研究热点主要集中在炎症反应、巨噬细胞、内皮细胞、平滑肌细胞等;并预测未来可能在细胞代谢、细胞凋亡、细胞因子等领域有较好的研究前景。结论近年来动脉粥样硬化发病机制领域研究关注度逐年提高,其研究范围与深度不断增加,本研究展示了该领域近10年的研究热点及前沿趋势,以期为其进一步深入研究提供参考。

Objective To analyze the research hotspots and trends of the pathogenesis of atherosclerosis in the past 10 years.Methods The related literatures on the pathogenesis of atherosclerosis from 2010 to 2019 in Science Citation Index-Expanded(SCI-E)of Web of Science(WOS)were included.CiteSpace software was used for co-occurrence analysis of authors,countries,institutions and disciplines,co-citation analysis of authors and journals,co-citation,clustering and clustering timeline analysis of literatures,and co-occurrence and summarization analysis of keywords.Results A total of 3320 literatures were retrieved.In the past 10 years,the volume of documents issued had been on the rise.The high-yield countries were dominated by the United States and China.The main research institutions were the University of Washington and other American universities.Weber C was the author with high output and citation frequency.The research subject was cardiovascular system and cardiology.In recent 10 years,the knowledge base of the research mainly focused on the fields of immunity and inflammation.Hot keywords focused on inflammatory response,macrophages,endothelial cells,smooth muscle cells,etc.The main research direction was to predict the metabolic and apoptosis mechanisms of macrophages and endothelial cells,and the related mechanisms of cytokines and their key mediators,such as inflammasome.Conclusion In recent years,the research focus in the field of atherosclerosis pathogenesis has been increasing year by year,and its research scope and depth are increasing.This study shows the research hotspots and frontier trends in this field in recent 10 years,in order to provide reference for further in-depth research.