摘要
抗肿瘤药物易使患者出现手足皮肤不良反应,严重影响生活质量,甚至影响化疗剂量或疗程,进而影响治疗效果。目前没有统一的治疗标准,西医主要采取大剂量维生素B6,COX-2抑制剂塞来昔布、糖皮质激素、尿素乳膏等,疗效不佳。通过查阅古籍及文献,手足皮肤不良反应属于"浸淫疮"、"指疔"、"鹅掌风""、瘑疮"范畴,并整理相关外治常用药,我们认为应根据皮损的不同临床表现辨证治疗。最终,将手足皮肤不良反应辨为气滞血瘀证、湿热热毒证、血虚风燥证、瘀毒阻滞证,在此基础上,分为"干性""、湿性",应用于临床治疗,初步取得较好疗效。
Hand and foot skin adverse reactions that caused by anticancer drugs,seriously affect the quality of life and even change the dose or interrupt treatment so that it can affect the effectiveness of treatment in serious cases.However,there is no unified treatment standard for this.The current treatments of Western medicine mainly rely on high-dose vitamin B6,cox-2 inhibitor celixib,glucocorticoid,urea cream,etc.But they have showed poor performance.By consulting classics of traditional Chinese medicine and literatures,the skin adverse reactions belong to"general effused eczema","pustule of fingertip","tinea manuum"and"palmoplantar pustulosis".We also organized related external treatment experience,and we thought the traditional Chinese medicine(TCM)therapies based on syndrome differentiation should be taken for different clinical manifestations of skin.Finally,we divided hand and foot skin adverse reactions into 4 TCM syndrome types,which were qi stagnation and blood stasis syndrome,dampness heat toxin syndrome,blood deficiency and wind dryness syndrome,and blood stasis and toxin stagnation syndrome.On this basis,it is divided into"dryness"and"dampness".It has been applied to clinical treatment and initially achieved good results.
作者
崔永佳
翁洁琼
卢雯平
Cui Yongjia;Weng Jieqiong;Lu Wenping(Guang'anmen Hospital of China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2021年第7期2487-2491,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
北京市科委科技计划项目(D161100005116005):中医药对三阴性乳腺癌患者术后复发转移的干预研究,负责人:王笑民、卢雯平。
关键词
抗肿瘤药物
手足皮肤不良反应
外治
辨证治疗
Anticancer drugs
Hand and foot skin adverse reactions
External treatment
Therapy based on syndrome differentiation