肥胖症患者袖状胃切除术后血小板相关指标的改变

Changes in platelet related parameters in obese patients after sleeve gastrectomy

探索肥胖症患者袖状胃切除术(SG)前后血小板相关指标的变化。回顾性分析2012年12月至2020年9月于北京协和医院行SG治疗的31例肥胖症患者临床资料。结果显示,与术前相比,术后2~12周血小板计数(PLT)显著减少(P=0.009),血小板分布宽度(PDW)、平均血小板体积(MPV)、大血小板比率(P-LCR)显著升高(P<0.001);术后16~55周PDW、MPV、P-LCR相对术后2~12周显著降低(P<0.01)。术后2~12周PLT与白细胞计数、中性粒细胞计数显著正相关,术后16~55周PLT与超敏C反应蛋白显著正相关(P<0.05)。

To compare changes in platelet related parameters in obese patients before and after sleeve gastrectomy(SG),we retrospectively analyzed the clinical data of 31 obese patients who underwent SG in Peking Union Medical College Hospital from December 2012 to September 2020.Results showed that compared with those before surgery,platelet count(PLT)decreased significantly at 2-12 weeks of follow-up(P=0.009),while platelet distribution width(PDW),mean platelet volume(MPV),and large platelet ratio(P-LCR)increased significantly at the same periods of follow-up after operation(P<0.001).However,the levels of PDW,MPV,and P-LCR began to decrease at 16-55 weeks when compared with those at 2-12 weeks of follow-up(P<0.01).PLT was positively correlated with white blood cells and neutrophils at 2-12 weeks of follow-up and positively correlated with high sensitivity C-reactive protein at 16-55 weeks of follow-up after operation(P<0.05).