帕利哌酮缓释片与阿立哌唑对青年女性首发精神分裂症的疗效及社会功能的影响

Study on the efficacy and social function of paripiprone sustained release tablets and aripiprazole in the treatment of first episode schizophrenia in young women

目的探讨帕利哌酮缓释片与阿立哌唑治疗青年女性首发精神分裂症的疗效及对社会功能的影响。方法选取我院2017年5月~2019年2月收治的72例首发精神分裂症青年女性患者,按随机数字表法分为两组,A组35例,B组37例,A组给予帕利哌酮,B组给予阿立哌唑,两组均连续治疗8周。观察两组患者治疗前、后血清催乳素、糖脂代谢、社会功能指标,并评定疗效。结果治疗第4周,A组PANSS评分显著低于B组(P<0.05);治疗第4周、第8周,两组血清PRL,与治疗前相比无显著差异(P>0.05);治疗第8周,两组脂代谢指标TG水平,均显著高于治疗前(P<0.05);B组糖代谢指标GLU水平,显著高于治疗前(P<0.05);治疗第4周、第8周,A组PSP评分显著高于同期B组(P<0.05);治疗期间,A组体重增加、镇静不良反应的发生率均显著高于B组(P<0.05);B组失眠、焦虑不良反应的发生率显著高于A组(P<0.05);A组总有效率80.00%,显著高于B组62.16%(P<0.05)。结论帕利哌酮与阿立哌唑治疗青年女性首发精神分裂症对血清催乳素无显著影响,对脂代谢均产生一定的影响,且阿立哌唑还会影响糖代谢水平,引起失眠、焦虑等不良反应,帕利哌酮的社会功能恢复力高于阿立哌唑,起效快于阿立哌唑,但8周后疗效相当,且会引起体重增加、镇静等不良反应。

Objective To investigate the efficacy of sustained release palaripiprone tablets and aripiprazole in the treatment of first episode schizophrenia in young women and their influence on social function.Methods 72 young female patients with first episode schizophrenia admitted in our hospital from May 2017 to February 2019 were randomly divided into two groups,35 in group A and 37 in group B.Group A was given pariprasidone,group B was given aripiprazole,both groups were treated for 8 weeks.Results At the 4th week,PANSS score of group A was significantly lower(P<0.05).There was no significant difference in serum PRL between the two groups at the 4th and 8th week(P>0.05).At the 8th week of treatment,TG level of lipid metabolism index in both groups was significantly higher(P<0.05).Glu level in group B was significantly higher(P<0.05).At the 4th and 8th week,the scores of PSP in group A were significantly higher(P>0.05).During the treatment,the incidence of weight gain and sedative adverse reactions in group A was significantly higher(P<0.05).The incidence of insomnia and anxiety in group B was significantly higher(P<0.05).The total effective rate of group A was significantly higher(P<0.05).Conclusion Paliperidone and aripiprazole in the treatment of young women with first-episode schizophrenia had no significant effect on serum prolactin,but had a certain impact on lipid metabolism.However,aripiprazole also affected the level of glucose metabolism,causing insomnia,anxiety and other adverse reactions.Paliperidone had a higher social function recovery than aripiprazole,and had a faster onset than aripiprazole.However,after 8 weeks of treatment,the efficacy of paliperidone was similar to that of aripiprazole Adverse reactions such as heavy increase and sedation.