摘要
目的分析肺炎支原体肺炎(MPP)患儿肠道菌群与血清干扰素-γ(IFN-γ)和白介素-4(IL-4)水平的关系。方法选取2016年10月~2020年10月我院收治的106例MPP患儿为研究对象,根据病程分为急性期组46例和恢复期组60例,并选取同期于本院进行体检的健康儿50例作为对照组,比较三组肠道菌群数量(双歧杆菌、真杆菌、乳酸杆菌、大肠杆菌、消化球菌)和血清IFN-γ、IL-4水平,并分析双歧杆菌、真杆菌、乳酸杆菌、大肠杆菌、消化球菌数量和血清IFN-γ、IL-4水平的相关性。结果急性期组和恢复期组双歧杆菌、真杆菌、乳酸杆菌、大肠杆菌、消化球菌数量低于对照组,急性期组双歧杆菌、真杆菌、乳酸杆菌、大肠杆菌、消化球菌数量低于恢复期组(P<0.05);急性期组和恢复期组血清IFN-γ、IL-4水平高于对照组,急性期组血清IFN-γ、IL-4水平高于恢复期组(P<0.05);Spearman相关分析显示,双歧杆菌、真杆菌、乳酸杆菌、大肠杆菌、消化球菌数量与血清IFN-γ、IL-4水平呈负相关性(P<0.05)。结论MPP患儿肠道菌群数量较少,血清IFN-γ、IL-4水平较高,且血清IFN-γ、IL-4水平随肠道菌群数量减少而升高。
Objective To analyze the relationship between intestinal floras and serum interferon-γ(IFN-γ),interleukin-4(IL-4)levels in children with Mycoplasma pneumoniae pneumonia(MPP).Methods A total of 106 MPP children admitted to the hospital from October 2016 to October 2020 were enrolled as the research objects.According to different courses of disease,they were divided into acute phase group(n=46)and recovery phase group(n=60).Fifty healthy children undergoing physical examination during the same period were enrolled as control group.The counts of intestinal floras(Bifidobacterium,Eubacterium,Lactobacillus,Escherichia coli,Peptococcus),serum IFN-γand IL-4 levels were compared among the three groups.The correlation between the intestinal floras and serum IFN-γ,IL-4 levels was analyzed.Results The counts of Bifidobacterium,Eubacterium,Lactobacillus,Escherichia coli and Peptococcus in acute and recovery phase groups were lower than those in control group,which were lower in acute phase group than recovery phase group(P<0.05).The levels of serum IFN-γand IL-4 in acute and recovery phase groups were higher than those in control group,which were higher in acute phase group than recovery phase group(P<0.05).Spearman correlation analysis showed that counts of Bifidobacterium,Eubacterium,Lactobacillus,Escherichia coli and Peptococcus were negatively correlated with serum IFN-γand IL-4 levels(P<0.05).Conclusion The number of intestinal floras is little,while levels of serum IFN-γand IL-4 are high in MPP children.The levels of serum IFN-γand IL-4 increase with the decrease of intestinal floras.
作者
胡尧舜
高广川
李小容
向豪
冯琴
HU Yaoshun;GAO Guangchuan;LI Xiaorong;XIANG Hao;FENG Qin(Department of Pediatrics, West China Guang'an Hospital, Sichuan University, Guang'an 638000, Sichuan, China)
出处
《西部医学》
2021年第11期1687-1690,共4页
Medical Journal of West China