牙囊干细胞应用于牙及牙周组织再生修复的前景及临床转化价值

Prospects and clinical transformation value on the application of dental follicle stem cells in the regeneration and repair of teeth and periodontal tissue

背景:牙囊干细胞作为牙源性间充质干细胞的一种,其优良的特性使其在细胞治疗以及组织工程方面具有良好的应用前景和临床转化价值。目的:综述牙囊干细胞的基本特性及其在牙及牙周复杂组织结构再生修复领域的最新进展。方法:以"dental follicle stem cell,regeneration,tooth,bone,periodontal tissue,tissue engineering,review"及"牙囊干细胞,再生修复,牙,骨,牙周组织,组织工程,综述"为关键词,检索PubMed、Sciencedirect、Medline、CBM、CNKI等数据库2010-2021年发表的文献,最后纳入61篇文献进行分析与讨论。结果与结论:牙囊干细胞作为牙源性间充质干细胞,在口腔再生医学领域拥有极大的应用价值,其具有来源丰富、多向分化、低免疫原性等特点。目前牙囊干细胞正积极应用于牙周缺损再生修复、组织工程生物牙根重建以及牙槽骨修复研究,近年来在其他组织损伤和免疫系统疾病的治疗潜能也被不断挖掘。但在更深入的临床应用之前,如何更好地调控牙囊干细胞的功能机制以及控制免疫系统反应,以进一步优化牙及牙周组织的构建方法,值得深入研究和探讨。

BACKGROUND:As a kind of dental mesenchymal stem cells,dental follicle stem cells have considerable application prospect and clinical transformation value in stem cell therapy and tissue engineering because of their excellent characteristics.OBJECTIVE:To review the basic characteristics of dental follicle stem cells and their latest progress in the field of regeneration and repair of tooth and periodontal complex tissue structure.METHODS:The key words were"dental follicle stem cell,regeneration,tooth,bone,periodontal tissue,tissue engineering,review"in Chinese and English.PubMed,Sciencedirect,Medline,CBM,CNKI,and other databases were retrieved in articles published from 2010 to 2021.Finally,61 articles were included for analysis and discussion.RESULTS AND CONCLUSION:As dental mesenchymal stem cells,dental follicle stem cells have great application value in the field of oral regenerative medicine,and they have the characteristics of rich sources,multi-directional differentiation,and low immunogenicity.At present,dental follicle stem cells are actively used in the regeneration of periodontal tissue,tissue engineering biological root reconstruction and alveolar bone repair.Their therapeutic potential in other tissue injuries and immune system diseases has been continuously explored in recent years.However,before more in-depth clinical application,how to better regulate the functional mechanism of transplanted dental follicle stem cells and control the immune system response,in order to further optimize the construction methods of teeth and periodontal tissue,is worthy of in-depth research and discussion.