超声、UE及PET/CT诊断乳腺癌良恶性病变的价值观察

Value of Ultrasound,UE,and PET/CT in the Diagnosis of Benign and Malignant Breast Lesions

目的探究超声、超声弹性成像(UE)以及正电子发射断层显像(PET/CT)在诊断乳腺癌良、恶性病变上的价值。方法选择2017年6月至2019年6月期间收治109例(116个病灶)乳腺癌患者作为研究对象,患者均行超声、UE以及PET/CT检查,其后穿刺活检或者手术获得病灶组织进行病理检查。分析超声、UE以及PET/CT诊断乳腺癌良、恶性诊断价值,比较乳腺良、恶性病灶超声特征、UE参数以及PET/CT参数。结果病理检查显示116个病灶中良性病变与恶性病变分别56个和60个;乳腺良性病变组病灶形态规则、无回声、边界清晰、0级与1级血流信号等超声特征比例均显著高于恶性病变组(P<0.05);乳腺良性病变组弹性模量均值、最大值等UE参数显著低于恶性病变组(P<0.05);乳腺良性病变组糖酵解总量、最大标准化摄取值以及肿瘤代谢体积等PET/CT参数显著低于恶性病变组(P<0.05);超声、UE、超声联合UE以及PET/CT诊断乳腺癌良、恶性Kappa值分别为0.554、0.690、0.897、0.741。结论超声特征、UE参数以及PET/CT参数有助于判断乳腺良、恶性病灶,超声联合UE对于乳腺良恶性诊断价值优于三种方式单一诊断。

Objective To explore the value of ultrasound,ultrasound elastography(UE),and positron emission tomography(PET/CT)in the diagnosis of benign and malignant breast lesions.Methods 109 patients with breast lesions(116 lesions)treated from June 2017 to June 2019 were selected as the research subjects.All of them were subjected to ultrasound,UE,and PET/CT examinations.Meanwhile,lesion tissues obtained by biopsy or surgery were collected for pathological examination.The value of ultrasound,UE,and PET/CT in diagnosing benign and malignant breast lesions were analyzed.The ultrasound features,UE parameters,and PET/CT parameters of benign and malignant breast lesions were compared.Results Pathological examination showed that among the 116 lesions,56 were benign,and 60 were malignant.The proportions of ultrasound features such as regular morphology,anechoic,clear boundaries,grade 0 and 1 blood flow signals in the benign group were significantly higher than those in the malignant group(P<0.05).UE parameters such as the mean and maximum elastic modulus of the benign group were significantly lower than those of the malignant group(P<0.05).PET/CT parameters such as total glycolysis,maximum standardized uptake value,and tumor metabolic volume of the benign group were significantly lower than those of the malignant group(P<0.05).Kappa values of ultrasound,UE,ultrasound combined with UE,PET/CT in diagnosing benign and malignant breast lesions were 0.554,0.690,0.897,and 0.741,respectively.Conclusion Ultrasound features,UE parameters,and PET/CT parameters are helpful for differential diagnosis of benign and malignant breast lesions.Besides,ultrasound combined with UE is superior to the single diagnosis of the three methods.