初探慢性精神分裂症患者脑白质磁共振DTI特点与临床特征的相关性

Correlation between the Magnetic Resonance DTI Characteristics of White Matter of Brain and Clinical Characteristics in Patients with Chronic Schizophrenia

目的分析慢性精神分裂症患者脑白质磁共振DTI特点与临床特征的相关性。方法收集本院2017年6月至2019年6月收治慢性精神分裂症患者81例,另选取同期在本院进行健康体检者81例。对患者所得图像进行分析,计算不同人群中SDDSS、WCST评分,分析不同人群中脑白质FA值变化情况及各临床症状评分与各区域FA值相关性。结果慢性精神分裂者SDDSS、WCST持续错误数均高于健康组,WCST完成分类数低于健康组(P<0.001);慢性精神分裂患者右颞中回FA值高于健康组,左额下回、右颞上回、右颞横回、右海马回、左岛叶则均低于健康组(P<0.001);右颞上回、右颞横回、右海马回FA值与患者病程为负相关(r=-0.635、-0.577、-0.536,P<0.05),与其他临床特征未见明显相关性(P>0.05)。结论慢性精神分裂症患者脑白质细微结构与健康者存在差异,FA值越低提示患者病情越严重。

Objective to analyze the correlation between the magnetic resonance DtI characteristics of the white matter of the brain and clinical characteristics in patients with chronic schizophrenia.Methods 81 patients with chronic schizophrenia who were admitted to our hospital from June 2017 to June 2019 were collected,and another 81 patients who underwent health examinations in our hospital in the same period were selected.the images of the patients were analyzed,the SDDSS and WCSt scores in different people were calculated,the changes in FA value of white matter of the brain in different people and the correlation between clinical symptoms scores and FA values in various regions were analyzed.results the number of sustained errors in SDDSS and WCSt in patients with chronic schizophrenia was higher than those in the healthy group,and the number of completed classification of WCSt was lower than that in the healthy group(P<0.001).the FA value of the right middle temporal gyrus in patients with chronic schizophrenia was higher than that in the healthy group.the FA values of the inferior frontal gyrus,right superior temporal gyrus,right transverse temporal gyrus,right hippocampus,and left insula were lower than those in the healthy group(P<0.001).the FA values of the right superior temporal gyrus,right transverse temporal gyrus,and right hippocampus were negatively correlated with the patient's disease course(r=-0.635,-0.577,-0.536,P<0.05),and there was no significant correlation between the FA values and other clinical features(P>0.05).Conclusion the fine structure of white matter in patients with chronic schizophrenia is different from that in healthy people.A lower FA value indicates a more severe condition.