氨溴特罗片辅助治疗小儿支原体肺炎的疗效及对机体免疫功能、炎症因子的影响

Effect of ambroterol tablets in adjuvant treatment of child mycoplasmal pneumonia and its effect on immune function and inflammatory factors

目的观察氨溴特罗片辅助治疗小儿支原体肺炎的疗效,探讨其对机体免疫功能、炎症因子的影响。方法纳入2018年2月至2019年3月西北大学附属神木医院收治的支原体肺炎患儿158例,按照随机数字表法随机分为对照组和观察组,各79例。对照组给予阿奇霉素及对症支持治疗,观察组在对照组基础上加用氨溴特罗片治疗。观察两组总有效率,分析、比较两组治疗前后免疫功能(CD3^(+)、CD4^(+)、CD8^(+)水平)、炎症因子[白细胞介素(IL)-17、单核细胞趋化蛋白-4(MCP-4)、巨噬细胞衍生趋化因子(MDC)]水平,以及核因子-κB(NF-κB)、可溶性髓系细胞触发受体1(sTREM-1)水平变化情况,对比两组不良反应发生情况。结果观察组总有效率为96.20%,显著高于对照组的86.07%(P<0.05)。治疗后两组患儿NF-κB、sTREM-1水平均低于治疗前(P<0.05),治疗后观察组患儿NF-κB、sTREM-1水平低于对照组(P<0.05)。治疗后两组IL-17、MCP-4、MDC水平均低于治疗前(P<0.05),治疗后观察组患儿IL-17、MCP-4、MDC水平低于对照组(P<0.05)。治疗后两组患儿CD3^(+)、CD4^(+)水平均高于治疗前(P<0.05),CD8^(+)水平均低于治疗前(P<0.05),治疗后观察组患儿CD3^(+)、CD4^(+)水平高于对照组(P<0.05),CD8^(+)水平低于对照组(P<0.05)。两组均未发生明显药物相关不良反应。结论氨溴特罗片辅助治疗小儿支原体肺炎疗效确切,可降低患儿NF-κB、sTREM-1水平,能通过减轻炎性反应、提高免疫功能而发挥作用,安全性良好。

Objective To observe the effect of ambroterol tablets in the adjvant treatment of child mycoplasmal pneumonia,and to explore its effect on immune function and inflammatory factors.Methods A total of 158 children patients with mycoplasmal pneumonia in Affiliated Shenmu Hospital of Northwest University from February 2018 to March 2019 were included and divided into the control group and observation group according to the random number table method,79 cases in each group.The control group was given azithromycin and symptomatic supportive treatment.The observation group was treated with ambroterol tablets on the basis of control group.The total effective rate was observed in the two groups.The immunologic function(CD3^(+),CD4^(+) and CD8^(+) levels),inflammatory factors(IL-17,MCP-4,MDC),NF-κB,sTREM-1 levels and adverse effects were analyzed and compared between the two groups.Results The total effective rate in the observation group was 96.20%,which was significantly higher than 86.07%in the control group(P<0.05).After treatment,the levels of NF-κB and sTREM-1 in the two groups were significantly lower than those before treatment(P<0.05).The levels of NF-κB and sTREM-1 after treatment in the observation group were significant lower than those in the control group.The levels of IL-17,MCP-4 and MDC in the two groups were significantly lower than those before treatment(P<0.05),the levels of IL-17,MCP-4 and MDC after treatment in the observation group were significantly lower than those in the control group(P<0.05).The levels of CD3^(+) and CD4^(+) after treatment in the two groups were significantly higher than those before treatment(P<0.05).The CD8^(+) level was lower than that before treatment(P<0.05).The levels of CD3^(+)and CD4^(+)after treatment in the observation group were higher than those in the control group(P<0.05),and the CD8^(+) level was lower than that in the control group(P<0.05).No drug-related adverse reactions occurred in the two groups.Conclusion Ambroterol tablets are definitely effective in the treatment of child mycoplasmal pneumonia,can reduce the levels of NF-κB and sTREM-1,play the effect by alleviating the inflammatory response and increasing the immune function,and have good safety.