乙型肝炎病毒感染患者肝硬化发生相关临床危险因素分析

Analysis of Clinical Risk Factors Related to Liver Cirrhosis in Patients with Hepatitis B Virus Infection

目的探讨乙型肝炎病毒感染患者肝硬化发生相关临床危险因素。方法选取2017年2月至2020年2月在我院就诊的乙型肝炎病毒感染患者98例,分为非肝硬化组28例,健康恢复组27例,肝硬化组43例。分析患者病史、病理及肝功能指标。结果98例乙型肝炎病毒感染患者,其中感染途径明确患者78例,慢性乙型肝炎组、健康恢复组垂直感染率依次为93.6%(44/47)、54.8%(17/31),慢性乙型肝炎组垂直感染率明显高于健康恢复组,且男性感染率明显高于女性(P<0.05);与健康恢复组比较,慢性乙型肝炎组AFP、Tbil、Glb、ALT、AST、ALP水平更高,Alb、GGT水平更低(P<0.05),可将病程、AFP及肝功能指标作为乙型肝炎病毒感染肝硬化危险因素。结论垂直感染、AFP及肝功能指标是引发乙型肝炎病毒感染肝硬化主要因素,若临床具备以上因素应及时干预,减缓肝硬化进程。

Objective To investigate the clinical risk factors of liver cirrhosis in patients with hepatitis B virus infection.Methods A total of 98 patients with hepatitis B virus infection in our hospital from February 2017 to February 2020 were selected and divided into non-cirrhosis group with 28 cases,healthy recovery group with 27 cases,and liver cirrhosis group with 43 cases.Analyze patient history,pathology and liver function indicators.Results There were 98 patients with hepatitis B virus infection,of which 78 patients had a clear route of infection.The vertical infection rates of chronic hepatitis B group and healthy recovery group were 93.6%(44/47)and 54.8%(17/31),respectively.The vertical infection rate of the hepatitis group was significantly higher than that of the healthy recovery group,and the infection rate of men was significantly higher than that of women(P<0.05);compared with the healthy recovery group,the levels of AFP,Tbil,Glb,ALT,AST,ALP in the chronic hepatitis B group Higher,lower levels of Alb and GGT(P<0.05),and disease course,AFP and liver function indicators can be used as risk factors for hepatitis B virus infection with liver cirrhosis.Conclusion Vertical infection,AFP and liver function indicators are the main factors that cause hepatitis B virus infection and liver cirrhosis.If the above factors are clinically available,timely intervention should be made to slow down the process of liver cirrhosis.