罗沙司他对初始透析患者肾性贫血的疗效及血红蛋白的影响

Effect of Roxastat on Renal Anemia and Hemoglobin in Initial Dialysis Patients

目的探讨初始透析患者应用罗沙司他对肾性贫血的疗效及对血红蛋白的影响。方法选择宁德市闽东医院2019年4月至2021年2月收治的64例初始透析肾性贫血患者,根据随机数字表法分为研究组(32例)和对照组(32例),对照组透析期间给予重组促红细胞生成素治疗,研究组应用罗沙司他治疗,观察两组血红蛋白、血清生化指标改善情况,比较临床疗效及用药安全性。结果治疗14d后,研究组血红蛋白(Hb)、红细胞压积(HCT)浓度较对照组高,差异有统计学意义(P<0.05);研究组血清铁蛋白(SF)、C-反应蛋白(CRP)、血肌酐(Scr)、血尿素氮(BUN)浓度较对照组低,差异有统计学意义(P<0.05);研究组的治疗总有效率为90.63%,略高于对照组的(75.00%),差异无统计学意义(P>0.05);研究组的不良反应发生率为6.26%,与对照组(0)相比,差异无统计学意义(P>0.05)。结论初始透析患者应用罗沙司他治疗肾性贫血,效果确切,可有效提高血红蛋白水平,改善血清生化指标,且用药安全性高。

Objective To investigate the effect of rosastat on renal anemia and the effect of hemoglobin on initial dialysis patients.Methods 64 patients with initial dialysis renal anemia admitted to Mindong Hospital in Ningde City from April 2019 to February 2021 were selected and divided into a study group(32 cases)and a control group(32 cases)according to the random number table method.The control group was treated with recombinant erythropoietin during dialysis,and the research group was treated with rosarestat.The improvement of hemoglobin and serum biochemical indicators of the two groups was observed,and the clinical efficacy and drug safety were compared.Results After 14 days of treatment,the concentrations of hemoglobin(Hb)and hematocrit(HCT)in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05);the serum ferritin(SF)and C-reactive protein(CRP),blood creatinine(Scr),and blood urea nitrogen(BUN)concentrations were lower than those of the control group,and the difference was statistically significant(P<0.05);the total effective rate of treatment in the study group was 90.63%,slightly higher than the control group’s 75.00%,the difference between the two groups of data was not statistically significant(P>0.05);the incidence of adverse reactions in the study group was 6.26%,compared with0.00%in the control group,the difference was not statistically significant(P>0.05).Conclusion The treatment of renal anemia with rosastat for initial dialysis patients has a definite effect.It can effectively increase hemoglobin levels and improve serum biochemical indicators,and the medication is safe.