博来霉素病灶内注射在皮肤科的临床应用

Intralesional Bleomycin for Dermatological Indications

博来霉素族抗生素属于氨基糖肽类的一个亚家族,是一种抗肿瘤抗生素。现阶段博来霉素族抗生素临床上容易获得且最常用的是博来霉素。博来霉素的主要作用机制是DNA链切割。博来霉素在皮肤科的应用主要包括难治性跖疣和甲周疣、瘢痕疙瘩和增生性疤痕、婴儿血管瘤、非黑色素瘤皮肤癌、皮肤转移瘤角化棘皮瘤等。博来霉素注射后的皮肤反应包括疼痛、红斑、水肿、发黑、焦痂形成、色素改变。偶尔报告的不良反应是坏疽、甲癣、雷诺现象、硬皮病和鞭挞样红斑。

Bleomycin family belongs to a subfamily of glycopeptide antibiotics and is utilized primarily as an antineoplastic agent.At present,bleomycin is the most clinically available and frequently used in bleomycin family antibiotics.Bleomycin’s main mechanism of action is DNA-strand scissoring.Its dermatological indications are refractory plantar and periungual warts,keloid,hypertrophic scars,infantile hemangioma,non-melanoma skin cancer,cutaneous metastases,keratoacanthoma and other indications.Local skin reactions after bleomycin injection include transient symptoms of pain,erythema,edema,blackening,eschar formation and pigmentary changes.Sporadic reported adverse reactions after intralesional administration include gangrene,onychodystrophy,Raynaud’s phenomenon,scleroderma and flagellate erythema.