新疆哈萨克族非酒精性脂肪肝与肥胖指数的相关分析

Correlation analysis of non-alcoholic fatty liver disease and obesity index in Xinjiang Kazakh

目的探讨哈萨克族非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)与新的肥胖指数[身体形态指数(a body shape index,ABSI)、身体圆度指数(body roundness index,BRI)、腰高比(wait height ratio,WHtR)]的相关性。方法选择2018年3月—2019年3月在新疆医科大学第一附属医院就诊的哈萨克族人群1266名进行病例对照研究,哈萨克族569例NAFLD患者为病例组,哈萨克族697例健康者为对照组,检测体质指数、血压、生化指标及肥胖相关指数(ABSI、BRI、WHtR)。采用单因素、多因素logistic回归分析及ROC曲线分析肥胖指标(基于Z-得分值)与NAFLD的关系。结果NAFLD组ABSI、BRI及WHtR均高于对照组;BRI(男性OR=5.796,女性OR=9.400)和WHtR(男性OR=5.994,女性OR=9.338)与NAFLD的关联度高于ABSI(男性OR=1.469,女性OR=1.803);男性BRI敏感性为81.9%,特异性为59.1%,女性敏感性为81.9%,特异性为73.3%;男性ABIS敏感性为60.8%,特异性为55.1%,女性敏感性为64.3%,特异性为79.5%;男性WhtR敏感性为81.9%,特异性为57.8%,女性敏感性为81.9%,特异性为71.0%。结论ABSI、BRI及WHtR与NAFLD密切相关,但ABSI与NAFLD的关联性弱于BRI和WHtR。

Objective To investigate the correlation between non-alcoholic fatty liver disease(NAFLD)and new obesity indexes[body shape index(ABSI),body roundness index(BRI),and waist height ratio(WHtR)]in Kazakh.Methods A total of 1266 Kazakh people who visited the First Affiliated Hospital of Xinjiang Medical University from March 2018 to March 2019 were selected for the case-control study,including 569 Kazakh cases with NAFLD in case group and 697 Kazakh healthy controls in control group.Body mass index(BMI),blood pressure,biochemical indexes,new obesity indexes(ABSI,BRI and WHtR)were measured.Univariate,multivariate logistic regression analysis and ROC curve were used to analyze the relationship between new obesity indexes(based on Z-score)and NAFLD.Results The levels of ABSI,BRI and WHtR in NAFLD group were higher than those in control group.The correlation between BRI(male OR=5.796,female OR=9.400),WHtR(male OR=5.994,female OR=9.338)and NAFLD was higher than that of ABSI(male OR=1.469,female OR=1.803).For BRI,the sensitivity and specificity in males was 81.9%and 59.1%respectively,while those in females was 81.9%and 73.3%respectively.For ABIS,the sensitivity and specificity in males was 60.8%and 55.1%respectively,while those in females was 64.3%and 79.5%respectively.For WhtR,the sensitivity and specificity in males was 81.9%and 57.8%respectively,while those in females was 81.9%and 71.0%respectively.Conclusion ABSI,BRI and WHtR are closely related to NAFLD,but the correlation between ABSI and NAFLD is weaker than BRI and WHtR.