血浆sCD14-st对重症急性胰腺炎严重程度及预后的评估价值

Evaluation Value of Plasma sCD14-st on the Severity and Prognosis of Severe Acute Pancreatitis

目的探讨血浆可溶性白细胞分化抗原14亚型(sCD14-st)水平评价重症急性胰腺炎(SAP)患者病情严重程度及预后的价值。方法选取2017年12月至2020年12月53例进入安徽医科大学附属安庆医院重症监护病房治疗的SAP患者,根据序贯器官衰竭评估(SOFA)将患者分为SOFA评分≥2分组与SOFA评分<2分组,比较两组研究对象12 h内不同时间点sCD14-st的水平,并分析不同时间点sCD14-st与SOFA评分二者之间的相关性,比较不同预后组sCD14-st的变化特点及差异。结果 SOFA评分≥2分组与SOFA评分<2分组比较,各时点sCD14-st水平均较高,差异具有统计学意义(P<0.05);不同时间点sCD14-st水平与SOFA评分呈正相关。不同时间点,死亡组sCD14-st水平均较高,差异具有统计学意义(P<0.05)。结论 sCD14-st水平对SAP分层诊断具有重要意义,病情越重患者sCD14-st水平越高,早期sCD14-st水平对SAP的预后具有预测价值。

Objective To investigate the value of plasma soluble CD14 subtype(sCD14-st) level in evaluating the severity and prognosis of severe acute pancreatitis(SAP) patients.Methods Fifty-three SAP patients admitted to Anqing Hospital Affiliated to Anhui Medical University intensive care unit were selected from December 2017 to December 2020 and divided into sequential organ failure assessment(SOFA) score ≥2 points group and SOFA score <2 points group according to the SOFA scoring standard.The levels of sCD14-st at different time points within 12 hours of the two groups were compared.The correlation between sCD14-st and SOFA score at different time points were analysed.The change characteristics and differences of sCD14-st in different prognosis groups were compared.Results Compared with SOFA score < 2 points group,sCD14-st level in SOFA score ≥2 points group was higher at each time point,and the difference was statistically significant(P<0.05).There was a positive correlation between sCD14-st level and SOFA score at different time points.At different time points,the level of sCD14-st in the death group was higher,and the difference was statistically significant(P<0.05).Conclusion The level of sCD14-st is of great significance for the diagnosis of SAP stratification.The more severe the disease,the higher the level of sCD14-st.The early sCD14-st level has predictive value for the prognosis of SAP.