胃癌患者HER2表达状态的影响因素分析

Factors Affecting the Expression of HER2 in Patients with Gastric Cancer

目的分析胃癌患者人表皮生长因子受体-2(HER2)阳性率,探讨影响胃癌患者HER2表达状态的因素。方法回顾性收集2016年1—12月郑州大学第一附属医院行外科手术治疗的198例胃癌患者的临床资料,采用免疫组织化学染色(IHC)和双色银染原位杂交(DSISH)检测患者HER2的表达情况,分析HER2阳性表达与胃癌患者临床特征及病理特征之间的关系。结果 198例胃癌患者中HER2阳性率为14.6%(29/198),单因素分析结果显示,胃癌患者HER2阳性表达与性别、分化程度、Lauren分型相关(P<0.05)。多因素分析结果表明,性别、分化程度是影响胃癌患者HER2阳性表达的独立因素。结论性别、分化程度是影响胃癌患者HER2阳性表达的独立因素,HER2阳性表达更常见于男性、中高分化型胃癌患者。

Objective To investigate the positive rate of HER2 in gastric cancer and analyze the factors affecting the expression of HER2 in patients with gastric cancer.Methods From January to December 2016,198 patients with gastric cancer were underwent surgery in the First Affiliated Hospital of Zhengzhou University,and data of these patients were retrospectively collected.The expression of HER2 was detected by immunohistochemistry and dual-color silver-enhanced in situ hybridization.Clinicopathologic features and other factors were analyzed to assess their influences on HER2 expression.Results The HER2-positivity rate was 14.6%(29/198) across analyzed tumor samples.The results from univariate analysis showed that HER2 expression was associated with gender,well to moderately differentiated tumors and Lauren intestinal histological subtype(P<0.05).The results from multivariate analysis showed that gender and well to moderately differentiated tumors were independent factors affecting the expression of HER2 in gastric cancer.Conclusion Gender and well to moderately differentiated tumors are independent factors affecting the expression of HER2 in gastric cancer.HER2 positive expression is more common in males and patients with well to moderately differentiated gastric cancer.